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Microbiology & Immunology Theses and Dissertations
This collection contains theses and dissertations from the Department of Microbiology & Immunology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2024 2024
Investigating the effects of physical maturation and sexual debut on HIV-1 susceptibility in adolescent males in Rakai, Uganda , Omar Almomani
Characterizing and Applying a Nasal Organotypic Model to Investigate the Effects of Immune Profile Types on SARS-CoV-2 Susceptibility , Victor H.K. Lam
Effect of sodium thiosulfate pre-treatment on renal ischemia-reperfusion injury , Pierce BR Nelson
Role of Ikzf3 as a Driver Mutation in B Cell Acute Lymphoblastic Leukemia , Heidi Rysan
Assessing Helicobacter pylori's HcpE and DsbK's Effects on Immunostimulation in Host Gastric Cells , Noor Salloum
Contribution of Streptolysin O and Streptolysin S to Streptococcus pyogenes Infections in HLA-Transgenic Mice , Blake A. Shannon
Regulation of ZAP-70 post-translational modifications by HIV-1 accessory proteins Nef and Vpu , Jack E. Teplitsky
Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia , Joshua S. Yi
Comparative Analysis of HIV-1 and SARS-CoV-2 Transmission Dynamics: Investigating Viral Fitness, Environmental Factors, and Pathogen-Host Interactions , Yiying Zhang
Investigating the role of two-component regulatory systems in regulating FnBP-A of Staphylococcus aureus , Yunqi Zhang
Theses/Dissertations from 2023 2023
The Effect of Kidney Preservation at 10°C with Hemopure and Hydrogen Sulfide Donor, Sodium Thiosulfate, in a Syngeneic Model of Rat Renal Transplantation , Maria Abou Taka
Mechanisms of lactic acid bacteria secretions as anti-Helicobacter pylori agents , Daelyn Carroll
Investigating the clinical and microbial factors contributing to calcium-containing kidney stone disease , John A. Chmiel
Elucidating the Biomechanics of MERTK-Mediated Efferocytosis , Brandon Hayato Dickson
SARS-CoV-2 infectivity potential in municipal wastewater: Implications for public health & water treatment , Justin Donovan
Development of a high-throughput approach for testing optimal fecal microbiota transplant material , Shaeley Jae Gibbons
The Role of Mucosa-Associated Invariant T Cells in an Autochthonous Mouse Model of Bladder Cancer , Inbar A. Habaz
Evaluating the role of GraS and FadXDEBA in promoting Staphylococcus aureus adaptation to host-derived fatty acids encountered at sites of colonization and infection , Robert C. Kuiack
The Effects of Cell Envelope Localization of FnBP-A on Staphylococcus aureus FnBP-A Dependent Phenotypes , Camille LeBlanc
The Role of the MEK1/2-ERK-RSK Signalling Axis in Innate Immune Memory , Rachel Low
Identification of a PU.1-regulated repressive region in Aicda gene locus , Allanna MacKenzie
Evolution of overlapping reading frames in virus genomes , Laura Muñoz Baena
Molecular Characterization of the Antiviral Properties of the Small HERC Family of Proteins , Ermela Paparisto
Effect of pharmacological inhibition of endogenous hydrogen sulfide production on bladder cancer progression , Sydney Relouw
Exploration of the Immune Landscape of EBV-associated Gastric Cancers , Mikhail Salnikov
Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway , Steven Trothen
Characterization of T-Cell Responses to Homocitrulline in a Mouse Model of Rheumatoid Arthritis , Sofya Ulanova
Inflammation in the Neovaginal Microenvironment of Transfeminine Individuals , Hannah M.J. Wilcox
Theses/Dissertations from 2022 2022
Investigation of the Binding and Outside-In Signalling Mechanisms of Anti-CD11d Acute Neurotrauma Therapy , Eoin N. Blythe
TetR family regulator FarR variation controls antimicrobial fatty acid efflux in Staphylococcus aureus , Camryn M. Bonn
The Role of Coagulase-Negative Staphylococcal Secreted Products on Staphylococcus aureus and Staphylococcus lugdunensis Infections , Denny Chin
Characterizing the Function of B Cells that Accumulate in the Inflamed Central Nervous System in Anti-Myelin Autoimmunity , Lika Chowdhury
The Streptococcus pyogenes hyaluronic acid capsule prevents neutrophil clearance, and greater insights into the streptococcal M protein as a vaccine candidate and driver of heart dysfunction , Jacklyn Hurst
In Vitro and In Vivo Characterization of the Metallodrug BOLD-100 as an Inhibitor of SARS-CoV-2 Replication , Daniel S. Labach
Regulation of MHC II Trafficking and Expression by Host and Viral Factors , Alex Lac
Design and Synthesis of Nef:SFK Interaction Inhibitors for Application in an Immune-directed HIV-1 Cure , Antony Lurie
Immunophenotyping and Functional Assessment of Antiviral CD8+ T Cells in a CLP Mouse Model of Immunosuppression , Alex R. Michaud
Herbicide Mediated Selection of Sulfonamide Resistant E. coli , Laura P. Muntz
Campylobacter jejuni Capsular Heptose: Moderation of Host Macrophages and Substrate Channeling During Synthesis , Matthew Myles
The role of reactive oxygen species in the accumulation of driver mutations in B cell acute lymphoblastic leukemia , Mia P. Sams
The Effect of Oral and Topical Antibiotics on Foreskin Inflammation and HIV Target Cells in Ugandan Men. , Zhongtian (Eric) Shao
Screening for purine transporters in S. aureus , Tothong Sonpaveerawong
The Expanding Roles of PACS-1 and PACS-2 in Cellular Physiology: Beyond Vesicular Protein Trafficking , Rong Xuan Zang
Theses/Dissertations from 2021 2021
Mucosa-Associated Invariant T Cells Undergo Phenotypic Changes Following Fecal Microbiota Transplantation , Jenna M. Benoit
Microbial innovations for disease management in honey bees , Brendan A. Daisley
Investigating the in vivo mechanism behind fibronectin binding protein-mediated hypervirulence of Staphylococcus aureus , Jaclyn A. Diamond
21°C is the emerging ideal temperature for kidney preservation in the presence of hydrogen sulfide , Smriti Juriasingani
Fishing for the right probiotic: Investigating the mechanism of mucosal-bacterial interactions at the interface of health and productivity in salmonid aquaculture , Luana Langlois
Testing a Novel Peptide-Infused Cream for Treatment of Rheumatoid Arthritis in DR4tg Mice , Alisha J. Moynahan
HIV-1 Drug Resistance to Integrase Strand Transfer Inhibitors in HIV-1 non-B Subtypes , Emmanuel Ndashimye
Metabolic Reprogramming By DNA Tumour Viruses , Martin Prusinkiewicz
Metabolic origins of urogenital malodour in women and their relationship with their microbiota: can probiotics help? , Scarlett Puebla Barragan
The E26 Transformation-Specific-Family Transcription Factor Spi-C is Dynamically Regulated by External Signals in B Cells , Hannah L. Raczkowski
Generation and Characterization of an In Vitro Organotypic Foreskin Model for Future Study of the Penile Microbiome , Geoffrey J. Rempel
The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function , Patrick Rudak
A Workflow to Analyze ETHcD Mass Spectrometry Data for Studying HIV gp120 Glycosylation , Yingxue Sun
Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion , Yodit Tesfagiorgis
Characterization and Discovery of Short Linear Motifs Mediating Protein Nuclear Import , Tanner M. Tessier
The Ability of Lactobacillus spp. to Limit Extracellular ATP Release by Urogenital Bacteria , Hannah Wilcox
Differential Effects of KIM-1 in Subcutaneous and Orthotopic Renca Models of Kidney Cancer , Demitra M. Yotis DY
Protective benefits of sodium thiosulfate-supplemented UW solution against prolonged cold ischemia-reperfusion injury during renal transplantation. , Max Y. Zhang Mr.
Theses/Dissertations from 2020 2020
Characterizing the Role of the Microbiome in Kidney Stone Disease , Kaitlin F. Al
Targeting CD5 to enhance immune T cell activation and function in treatment of solid tumours , Faizah Alotaibi
HPV Mediated Antagonism of the IL-18 Proinflammatory Pathway in Head and Neck Cancer , Wyatt W. Anderson
Investigation of the growth and survival of Staphylococcus aureus in CFTR-deficient macrophages , Bita Azad
Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition , Izabela Z. Batko
Understanding Neonicotinoid Related Immunosuppression: A Potential for Beneficial Bacterial Intervention , John A. Chmiel
Exploiting the immunomodulatory potentials of iNKT cells in sepsis and cancer. , Joshua Choi
Optimizing Fecal Microbiota Transplantations For Therapeutic Use Beyond Clostridioides difficile Infection , Laura J. Craven
Cell-free DNA Release During Programmed Cell Death in Kidney Ischemia Reperfusion Injury , Alexander Dionne
The development of bacterial magnetic resonance imaging for microbiota analyses , Sarah C. Donnelly
Inducing DNA-Mismatch Repair Deficiency In Tumours: A Strategy To Enhance Anti-Tumour Immunity , Mikal El-Hajjar
Investigating the Regulation of Fatty Acid Efflux Pump FarE by TetR Family Regulator FarR in Staphylococcus aureus , Katherine A. Ferguson
Elucidating the Role of Host Tim-1 in Anti-tumour Immunity , Ingrid Hon
Kidney Injury Molecule-1 Mediated Phagocytosis and Its Therapeutic Application in Ameliorating Renal Transplant Ischemia Reperfusion Injury , Ji Yun Lee
B Cell Acute Lymphoblastic Leukemia is Driven by Activating Janus Kinase Mutations Cooperating with Spi1 and Spib Deletions in a Murine Model , Michelle Lim
Development and evaluation of a heterogenous virus-like particle (VLP) formulation to achieve HIV-1 latency reversal and cure. , Joshua P. Pankrac
Designing a Novel HIV-1 Candidate Vaccine , Rahul Pawa
Identification of the Signalosome and Signaling Pathway of the Efferocytic Receptor MERTK , Tarannum Tasnim
Theses/Dissertations from 2019 2019
Potential role of extracellular ATP released by bacteria in bladder infection and contractility , Behnam Abbasian
Brain-specific and systemic inflammatory response following repetitive concussive impact in a mouse model , So Young Eo
The Group A Streptococci Bacteriocins Facilitate a Competitive Advantage During Nasopharyngeal Infection , Lana Estafanos
The Epigenetic And Immune Landscapes Of HPV+ Tumor Microenvironments , Steven F. Gameiro
Utilizing FIV (Feline Immunodeficiency Virus) to develop a novel animal model to study HIV (Human Immunodeficiency Virus) , Ankita Suryakant Kambli
Designing An Optimal HIV-1 Env Immunogen For The Vesicular Stomatitis Virus Vaccine Platform And Elucidating The Role Of HIV-1 Nef In Env Trafficking , Jason Knapp
Novel insights into the genomic integration site landscape of HIV-1 and other retrovirus genera , Hinissan P. Kohio
The role of kidney injury molecule-1 in the metastasis of renal cell carcinoma , Jasper Lee
Encountering Lectins In The Recipient Mucosa: Implications Of N-linked Glycosylation On HIV-1 Transmission , Adam Meadows
Endogenous, controlled expression of anti-HIV-1 broadly neutralizing antibody , Darshit Patel
Role of the fibronectin-binding, collagen-binding, T-antigen region during nasopharyngeal infection by Streptococcus pyogenes , Akshay Sule
HIV-1 Group M Subtype Fitness, Disease Progression, and Entry Efficiency , Colin M. Venner
Mucosa-Associated Invariant T Cell Roles And Local Responses In Cell-Mediated Immunity To Influenza A Virus , Christine Marie Wardell
Metabolomic and Genomic Analysis of Lactobacillus crispatus Vaginal Isolates , Emiley Watson
Virally Packaged RNA in Virus-Like Particle Vaccines Enhances Antigenicity and Augments Latency Reversal of HIV-1 , Chanuka Wijewardhana
Determining the Relative Transmission Fitness of HIV-1 Subtypes A, B, C, and D , Spencer Yeung
The Role of Defective Macrophage Efferocytosis During Early Atherosclerosis in Humans , Charles Yin
Theses/Dissertations from 2018 2018
Characterization of Urinary Microbiome and Their Association with Health and Disease , Yige Bao
Characterization of interleukin (IL)-1β regulatory elements and chromatin conformation in macrophage activation , Woohyun Cho
Determining the Molecular Mechanisms of PACS-1-mediated Protein Sorting , Brennan S. Dirk
19F-MRI to Monitor Therapeutic Cell Migration and Distribution , Corby Fink
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UKnowledge > College of Medicine > Microbiology, Immunology, and Molecular Genetics > Theses & Dissertations
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Theses/dissertations from 2024 2024.
Contributions of the Replication Initiator Protein DnaA to Physiology and Virulence of the Lyme Disease Spirochete , Andrew Krusenstjerna
AZITHROMYCIN ALCHEMY: A JOURNEY FROM PRECISION IMMUNOMODULATION TO TARGET EXPLORATION AND BEYOND , Hodaossadat Saghaeiannejad Esfahani
THE ROLE OF INTRACELLULAR GROWTH DURING THE SYSTEMIC SPREAD OF LISTERIA MONOCYTOGENES , Jamila S. Tucker
Theses/Dissertations from 2023 2023
Investigation of Key Mechanisms of Contact Dependent Growth Inhibition Systems in Burkholderia cepacia Complex Species , Zaria K. Elery
Investigating the relationship between metabolic reprogramming and peripheral CD4+ T-cell inflammation in human type 2 diabetes pathogenesis , Gabriella Kalantar
SUBSTRATE SELECTION AND EFFECTOR GATING IN THE HELICOBACTER PYLORI CAG TYPE IV SECRETION SYSTEM , Mackenzie E. Ryan
Theses/Dissertations from 2021 2021
APPLICATION OF GENETIC TECHNIQUES TO INVESTIGATE CHLAMYDIA TRACHOMATIS TYPE III SECRETION EFFECTOR BIOLOGY , Gabrielle Keb
CHARACTERIZING THE PHYSIOLOGY AND GENETICS OF CONTACT DEPENDENT GROWTH INHIBITON SYSTEMS IN BURKHOLDERIA SPECIES , Alice Elizabeth Oates
Theses/Dissertations from 2020 2020
Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury , Evan Lynch
MAST CELLS AS NOVEL EFFECTOR CELLS IN THE PATHOGENESIS OF CHRONIC GRAFT-VERSUS-HOST DISEASE , Ethan Strattan
Theses/Dissertations from 2019 2019
THE ROLE OF CD8 T CELL IMMUNODOMINANCE AND REGULATORY T CELLS IN NEONATAL IMMUNITY TO INFLUENZA VIRUS , Luke Heil
EVOLUTION OF THE ZHX TRANSCRIPTION FACTOR FAMILY AND ANALYSIS OF ZHX2 TARGET GENES CYP2A4 AND CYP2A5 IN MOUSE LIVER , Alexandra Nichole Nail
FUNCTIONAL ANALYSES OF THE DNA- AND RNA-BINDING PROTEIN SPOVG IN BORRELIA BURGDORFERI , Christina R. Savage
Theses/Dissertations from 2018 2018
INSIGHTS INTO KEY GENE REGULATORY NETWORKS IN BORRELIA BURGDORFERI , William Kenneth Arnold
THE ROLE OF PRO-INFLAMMATORY MEDIATORS IFNβ AND PROSTAGLANDIN E2 IN SUPPRESSION OF INNATE IMMUNITY TO LISTERIA MONOCYTOGENES , Michelle G. Pitts
Theses/Dissertations from 2017 2017
SUPPRESSION OF ANTI-TUMOR IMMUNITY IN CHRONIC LYMPHOCYTIC LEUKEMIA VIA INTERLEUKIN-10 PRODUCTION , Sara Alhakeem
ANTISENSE AFP TRANSCRIPTS IN MOUSE LIVER AND THEIR POTENTIAL ROLE IN AFP GENE REGULATION , Maria S. Dixon
IMMUNE EVASION BY DIVISION OF LABOR: THE TROPHIC LIFE CYCLE STAGE OF PNEUMOCYSTIS MURINA SUPPRESSES INNATE IMMUNITY TO THIS OPPORTUNISTIC, FUNGAL PATHOGEN , Heather M. Evans
ROLE OF INTRACELLULAR GROWTH DURING THE GASTROINTESTINAL STAGE OF LISTERIA MONOCYTOGENES INFECTION , Grant Steven Jones
NOVEL ROLE OF PROSTATE APOPTOSIS RESPONSE-4 TUMOR SUPPRESSOR IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA , Mary Kathryn McKenna
THERAPEUTIC POTENTIAL OF TARGETING REACTIVE OXYGEN SPECIES (ROS) STRESS IN MYELODYSPLASTIC SYNDROME (MDS) , Karine Z. Oben
Theses/Dissertations from 2016 2016
Expression of Zinc Fingers and Homeoboxes 2 (Zhx2) and Zhx2 Target Genes in Multiple Tissues of Wild-Type and Zhx2 Knockout Mice , Minen Al-Kafajy
Theses/Dissertations from 2015 2015
THE ROLE OF BATF2 IN LPS/IFNγ POLARIZED MACROPHAGES , Marie A. Gehman
Theses/Dissertations from 2013 2013
ON T CELL FATE DECISIONS: RETINOL, METABOLISM AND ITREG DIFFERENTIATION , Gavin I. Ellis
Theses/Dissertations from 2012 2012
Role of the Immune System and Bioactive Lipids in Trafficking Bone Marrow-Derived Stem Cells in Patients with Ischemic Heart Disease , Ahmed Abdel-Latif
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View all UBC microbioloby and immunology theses via UBC Open Collections. Here are some of the most recent ones.
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