biochemistry research proposal sample pdf

Excellent opening paragraph stating why is the research important and leading to the research goals

Clear and concise presentation of research aims \(questions\)

Research plan is well \ detailed starting from third paragraph.

Pronoun problem: who is the "w\ e"? Earlier, "I" is very clear, but this "we" lacks a clear antecedent.

Writing tip: good use of "signa\ l" words \("first," "second"\) to organize information and highlight key points.

Contributors: P. Pazos, Searle Center for Teaching Excellence and P. Hirsch, The Writing Program, [email protected]

Posted: 2008

TITLE: The Mitochondrial Stress Response and the Communication of Stress Responses Between Subcellular Compart\ ments

Compelling presentation of preparation from courses and prior lab experience.

Very detailed presentation of techni\ ques learned that are relevant to the project

Writing tip: "data" is a p\ lural word. Say, "The data suggest. . . " and "they [meaning the data] indicate."

Overall comments:

Good quality proposal overall. The author clearly explains the aims a\ nd methods to carry out those aims.

Research question: Analysis of mitochondria's unfolding protein response and its crosstalk with other folding envir\ onments in the cell.

Compelling presentation of prior experience in courses and labs. Could include specific techniques learned.

Good use of citations and references

Suggestions:

Should add headings to make it more readable and add some structure.

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35911 Overview of the Research Proposal

• Published: August 2008
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In this module, we focus on writing a research proposal, a document written to request financial support for an ongoing or newly conceived research project. Like the journal article (module 1), the proposal is one of the most important and most utilized writing genres in chemistry. Chemists employed in a wide range of disciplines including teaching (high school through university), research and technology, the health professions, and industry all face the challenge of writing proposals to support and sustain their scholarly activities. Before we begin, we remind you that there are many different ways to write a successful proposal”far too many to include in this textbook. Our goal is not to illustrate all the various approaches, but rather to focus on a few basic writing skills that are common to many successful proposals. These basics will get you started, and with practice, you can adapt them to suit your individual needs. After reading this chapter, you should be able to do the following: ◾ Describe different types of funding and funding agencies ◾ Explain the purpose of a Request for Proposals (RFP) ◾ Understand the importance of addressing need, intellectual merit, and broader impacts in a research proposal ◾ Identify the major sections of a research proposal ◾ Identify the main sections of the Project Description Toward the end of the chapter, as part of the Writing on Your Own task, you will identify a topic for the research proposal that you will write as you work through this module. Consistent with the read-analyze-write approach to writing used throughout this textbook, this chapter begins with an excerpt from a research proposal for you to read and analyze. Excerpt 11A is taken from a proposal that competed successfully for a graduate fellowship offered by the Division of Analytical Chemistry of the American Chemical Society (ACS). As is true for nearly all successful proposals, the principal investigator (PI) wrote this proposal in response to a set of instructions. We have included the instructions with the excerpt so that you can see for yourself how closely she followed the proposal guidelines.

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Requirements, research proposal, research proposal and preliminary oral examination.

The preparation and defense of an original research proposal serves as the second portion of the preliminary examination. For this portion, there exists a Proposal Evaluation Committee (PEC) to consist of the student's entire graduate committee except for the member from outside the school. The school chair, if serving on the graduate committee as an ex-officio member, will be a non-voting member of this PEC. Initial work on the proposal should be initiated when the student begins taking cumulative examinations, as the first draft of the written proposal (see below) must be submitted to the PEC before the end of the student's fifth semester. Failure to submit the draft by the end of the fifth semester will result in discontinuation of assistantship support until the requirement is fulfilled. The student chooses the topic for an original research proposal. The topic must be approved by the Proposal Evaluation Committee (PEC) at a meeting in which the student outlines the proposal idea. The topic may use the techniques of the student's research project, but must not be an extension of the project. The proposal must be original with the student. After obtaining approval of the topic, the student will prepare a written proposal in accord with the prescribed format. (See Appendix IV.) During preparation, the student may obtain advice and suggestions from any faculty member but the proposal itself must be original with the student. The student must complete preparation of the proposal and submit it to the PEC before January of his or her third calendar year. The committee is allowed one week for evaluation of the proposal. The evaluation will include at least one meeting of the PEC. The evaluation shall be by a numerical score from 1.0 (lowest) to 4.0 (highest). An average score of 3.0 shall be required to pass. The scores will be accompanied by a written review by each voting PEC member. If the score is less than 3.0, the proposal must be revised and resubmitted within 30 days. The re-evaluation will follow the same procedure as described above. Only one re-submission is allowed. A second failure will be reported in writing by the PEC to the School Chair and to the Director of Graduate Studies. The latter will request that the Graduate School terminate the student from our doctoral program. In most cases, the students will be eligible for a Master’s degree. When the score is less than 3.0, copies of the final approved proposal must be provided to all members of the student's graduate committee at least one week before the date of the preliminary oral examination. Within 30 days of receiving notification of a passing grade, the student shall schedule a preliminary oral examination (defense of the proposal). This oral defense shall consist of a formal open seminar at which the student will present the proposal for credit as Chemistry 595. After questions from the general audience, the student's graduate committee will conduct an oral examination of the student. The grade for Chemistry 595 is based on the oral presentation and is independent of the oral examination. Only one attempt is allowed to pass the preliminary oral examination (defense of the research proposal). However, if the committee cannot decide whether to pass or fail the student at the end of the scheduled examination time, they may vote to continue the examination at a later date. Only one such continuation is allowed. The decision of the committee to pass the student or to continue the examination must be made with a majority vote of the committee. The student, the School Chair, and the director of graduate studies will be notified by the Chair of the graduate committee in writing on the next working day after the examination whether the result was Pass, Fail, or Continue. If a continuation is required, it must be scheduled no earlier than 30 days and no later than 90 days after the original oral examination date. Students in the Ph. D. program must complete the proposal defense by the end of third year in residence. Failure to complete the proposal defense by the end of third year will result in discontinuation of assistantship support until the requirement is fulfilled. If the student has not completed the defense by the end of the third year, the student will have one semester in which to complete the proposal defense (without assistantship support). Failure to complete the proposal by the deadline will result in termination from the graduate program. 4/5  Effective 12/13/07

A research project is required of all graduate students. A student in the doctoral program must earn at least 32 credit hours in research and dissertation (Chemistry 598 and 600). A minimum of 24 hours must be dissertation credit (Chemistry 600). The results of the research must be presented in the form of a dissertation acceptable both to the student's committee and to the Graduate School.

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Students undertake a research project lasting eight weeks offered by members of the Department (see: https://www.bioc.cam.ac.uk/people/uto ).  Please note that not all Group Leaders will host a research project every year because of sabbatical leave.  Projects may also be undertaken at other Cambridge locations such as the Gurdon Institute for Cancer and Developmental Biology, the Systems Biology Institute, the Cambridge Institute for Medical Research, the Department of Clinical Biochemistry (Institute of Metabolic Science), the Department of Veterinary Medicine, the MRC Dunn Human Nutrition Unit, the MRC Laboratory of Molecular Biology, the Hutchison/MRC Research Centre, the Unilever Cambridge Centre for Molecular Informatics and the Department of Chemical Engineering and Biotechnology.

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Biochemistry Research Proposals Samples For Students

3 samples of this type

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Ph.D. Thesis Proposal

Procedures and policy guidelines, a. procedures.

The Graduate Advisory Committee (GAC) evaluates all Ph.D. Thesis Proposals. The GAC consists of at least seven (7) faculty members of the Department, and of one graduate student representative. Current GAC faculty members can be found online*.

• Graduate students must present their Thesis Proposals in the 5th or the 6th semester of their graduate studies.
• The Graduate Advisory Committee convenes twice a year to evaluate proposals (Fall and Spring).
• Proposals are usually scheduled near the end of semesters (December, May).

Before the Examination

• Graduate students must have passed (overall satisfactory) their yearly presentation in front of a Research Advisory Committee (RAC), with the more recent RAC no more than 6 months.
• Permission to present a Ph.D. Thesis Proposal is required and should be clearly stated in the most recent RAC report.
• The title of the Ph.D. Thesis Proposal must be submitted at least five (5) weeks in advance of the examination to Pascale Joseph ( undergrad.biochem [at] mcgill.ca ).
• The complete written Ph.D. Thesis Proposal must be submitted at least three (3) weeks in advance to Pascale Joseph.
• The written proposal must be prepared and formatted as described in Appendix A  below.
• The student must prepare a twenty (20) minute oral presentation of their Ph.D. The presentation should not be longer than 20 minutes. Thesis Proposal (PowerPoint or the like) as instructed in Appendix B below.

Thesis Proposal Examination

• Examinations are done in person and should take no more than 1 hour. This is usually conducted in room 908 of the Biochemistry Department.
• Before the start of the examination, the GAC will meet without the student to review the student’s progress (RAC reports, course performances, Junior Seminar evaluation), flag any areas of concern, and discuss the written Ph.D. Thesis Proposal.
• The student will deliver a 20-minute oral presentation of their Ph.D. Thesis Proposal. The overall question period should last no longer than approximately 40 minutes.
• The meeting outcome (satisfactory, conditional, or unsatisfactory)
• Identify any areas of concern and corrective actions
• Determine any other advice to be provided to the students
• Based on the outcome, set the date of the next meeting if necessary
• The GAC Chair will summarize the examination outcome in a letter to be submitted to the graduate student and supervisor.
• Graduate students must register to the BIOC702 (Ph.D. Thesis Proposal) course.

B.  Policy on Ph.D. Thesis Proposal Procedure and Outcome

The Ph.D. Thesis Proposal examination consists of the following three (3) components:

• The written Thesis Proposal . The written proposal must be prepared and formatted as per Appendix A. Incomplete or poorly written proposals will impact the GAC’s decision and examination outcome. Failure to submit the written proposal in due time may also impact the student’s status in the program.
• The oral presentation . The oral presentation should summarize the content of the written document and be prepared as outlined in Appendix B. The student should be able to defend their Thesis Proposal based on the presentation. Presentations that are poorly prepared or that last longer than 20 minutes will impact the GAC’s decision and examination outcome.
• Answers during the question period . General competence will be assessed in the question period. Students must be able to discuss and explain presented experiments and provide details as needed. They must be able to elaborate beyond what is shown in the presentation (e.g. provide alternative questions, experiments, analyses, interpretations). They must demonstrate some general knowledge outside of their immediate research by answering connected and general questions in their research fields. Failure to demonstrate competence could impact the GAC’s decision and examination outcome.

Each component of the exam will be rated as Satisfactory , Conditional , or Unsatisfactory . The overall outcome of the Ph.D. Thesis Proposal is determined as follows:

Satisfactory

When all 3 components are rated as Satisfactory, the student will be deemed to have completed all three components and will receive a “PASS” grade on the BIOC702 course (Ph.D. thesis Proposal). The next meeting will be with a RAC at their yearly presentation.

Conditional

If one or more of the components is rated as less than Satisfactory and no more than one component is Unsatisfactory , the student will be graded as “CONDITIONAL”. In the letter submitted to the student and supervisor following the examination, the GAC will impose one or more condition and a timeline for the student to fulfill them (normally no more than 3 months). If the student fulfills the conditions set by the GAC, the student will be awarded a “ Satisfactory ”, be given a “PASS” for BIOC702, and be granted permission to continue in the program. If not, the meeting outcome will be deemed “ Unsatisfactory ”, and the procedures outlined in the following section will be followed.

Unsatisfactory

When two (2) or more components of the exam are rated as Unsatisfactory, the overall meeting outcome will be graded as “UNSATISFACTORY”. In keeping with GPS regulations**, the following consequences will result:

In the case where a student is unsuccessful at the first attempt of the exam:

• A grade of “HH – to be continued” will be recorded for BIOC702
• The student will be required to repeat the entire exam at a time determined by the GAC. As per GPS regulations, this meeting must occur not sooner than 4 months and not later than 6 months after the first meeting.
• A student who is successful in the second attempt will be deemed to have passed the exam, and will be given a “PASS” for BIOC702.

In the case where a student is unsuccessful at the second attempt of the exam:

• The student will be deemed to have failed the Ph.D. Thesis Proposal.
• A grade of “FAIL” will be entered for BIOC702 replacing the previously recorded HH. The student will be required to withdraw from the program.

Preparing and formatting the written Ph.D. Thesis Proposal

The written Ph.D. Thesis Proposal should be prepared with the oral presentation in mind. This document should properly introduce the project, justify its importance, describe your research progress to date, and propose future experiments that will overall represent an important contribution to research. The Ph.D. Thesis Proposal should feature substantial preliminary experimental work and propose future experiments . The proposed experiments should be well thought of and feasible.

• Approximately and not more than 5 pages single spaced including figures.
• Figures should be inserted in line with the text, be legible, and not exceed 1 page of total space.
• References are not included in the document’s 5 page maximum.
• The main text should provide the following:
• Central hypothesis
• Specific Aims: these could represent your proposed thesis chapters. Three (3) proposed results Chapters is common but not required. In each of your Aims, specify the short and long term objectives.
• Significance
• You can include extra pages reporting additional work that does not fit in the main Thesis Proposal. This is optional and should be clearly marked as an Appendix.
• Document must be letter size (21.25 x 27.5 cm / 8.5 x 11 inches).
• In the header on the left, indicate your name (the lab you are in).
• In the header on the right, indicate the section title (Ph.D. Thesis Proposal)
• In the footer, include the page number (center) and date (right)
• A minimum margin of 2 cm all around the page is mandatory.
• Use a font size of 12 point. Single line spacing. No condensed type or spacing.
• Each section of your document should be properly separated (e.g. skip a line between sections, use bold font for section titles, etc.)
• Figures must have legends.

As per GPS ruling:

“The work submitted for this assessment is expected to be your own. The use of technologies such as ChatGPT are prohibited and will be considered a violation of the Code of Student Conduct.”

Preparing the Ph.D. Thesis Proposal presentation

The Ph.D. Thesis Proposal presentation should summarize the written proposal. It should contain everything needed to explain and defend the project and proposed experiments. With the presentation, you should be able to convince the Examiners that the Proposal is Satisfactory . Importantly , the Ph.D. Thesis Proposal is not merely a progress report: it should also clearly propose future experiments.

Your oral presentation should last approximately 20 minutes and not more. You can choose to have questions during your presentation or only after. The question period should last no more than 40 minutes.

The presentation should:

• Properly introduce the research question and project .
• Clearly state the main hypothesis, Aims and proposed experiments.
• Include substantial preliminary experimental work. You must clearly specify who did the presented experiments. Acknowledge the contribution of others where relevant. This includes figures or data published elsewhere, which must be accompanied by a citation.
• Clearly outline future directions and propose new experiments.

Evaluation criteria

• Quality and clarity of the presentation and it’s delivery.
• Quality of responses to questions about the design, background, and potential of the project. This includes experiments already performed and those suggested as future directions.
• Quality of responses to general background questions about biochemistry and molecular biology.
• Response to criticism raised during the Research Seminar 1 (Junior) examination.
• Feasibility of the proposed experiments.

Important note

• It is the responsibility of the student to inform themselves of the Ph.D. Thesis Proposal Procedures, Policy and deadlines. Failure to comply can lead to expulsion from the program, unless strong justification is provided and confirmed in writing by the Supervisor.
• The methods adopted for examination and evaluation are specified by Departmental regulations and are in agreement with the Graduate Studies guidelines approved by the Dean of Graduate and Postdoctoral Studies, McGill University.

Quick Guidelines

Before the examination:.

• Title of the proposal submitted five weeks in advance to Christine Laberge
• Complete written proposal submitted three weeks in advance to Christine Laberge
• Up to five pages single spaced
• Describe research progress to date, and proposed (future) research for the Ph.D. thesis
• Optional extra page indicating additional work not in the main proposal may be added and must be clearly marked
• Present the background, rationale, central hypothesis, specific aims and significance
• Include short and long term objectives
• Three proposed results chapters is common but not required
• Must include substantial preliminary experimental work

Thesis Proposal Examination:

• 20 minute presentation to GAC, 40 minute discussion
• Presentation summarizes the written proposal
• Questions about the design, background and potential of the project
• Questions about general background knowledge of biochemistry and molecular biology

Evaluation Criteria:

• Presentation, background knowledge and insight into the proposed research
• Knowledge in related areas of biochemistry
• Response to criticisms raised during the Research Seminar 1
• Feasibility of the proposed experiments

Revised: April 2023

*    Graduate Advisory Committee Members (GAC)

**  Graduate Student Supervision

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Biochemistry Idea Papers: Teaching Proposal Writing

• In the Classroom
• Published: August 1999
• Volume 4 , pages 125–127, ( 1999 )

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• Anne M. Rammelsberg 1  

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A biochemistry course for upper-division students builds valuable skills for students seeking industrial positions or to continue their education. Some of these skills are the abilities to think critically, read the primary literature, write coherently, and come up with new directions for research. This assignment pushes students to gain mastery on a topic of interest, develop a preliminary idea, and develop scientific writing skills. This paper describes how this complex activity can be incorporated into the undergraduate setting, using finite steps to facilitate student success.

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Correspondence to Anne M. Rammelsberg .

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Rammelsberg, A.M. Biochemistry Idea Papers: Teaching Proposal Writing. Chem. Educator 4 , 125–127 (1999). https://doi.org/10.1007/s00897990314a

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Issue Date : August 1999

DOI : https://doi.org/10.1007/s00897990314a

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