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• Pediatr Investig
• v.3(4); 2019 Dec

Clinical research study designs: The essentials

Ambika g. chidambaram.

1 Children's Hospital of Philadelphia, Philadelphia Pennsylvania, USA

Maureen Josephson

In clinical research, our aim is to design a study which would be able to derive a valid and meaningful scientific conclusion using appropriate statistical methods. The conclusions derived from a research study can either improve health care or result in inadvertent harm to patients. Hence, this requires a well‐designed clinical research study that rests on a strong foundation of a detailed methodology and governed by ethical clinical principles. The purpose of this review is to provide the readers an overview of the basic study designs and its applicability in clinical research.

Introduction

In clinical research, our aim is to design a study, which would be able to derive a valid and meaningful scientific conclusion using appropriate statistical methods that can be translated to the “real world” setting. 1 Before choosing a study design, one must establish aims and objectives of the study, and choose an appropriate target population that is most representative of the population being studied. The conclusions derived from a research study can either improve health care or result in inadvertent harm to patients. Hence, this requires a well‐designed clinical research study that rests on a strong foundation of a detailed methodology and is governed by ethical principles. 2

From an epidemiological standpoint, there are two major types of clinical study designs, observational and experimental. 3 Observational studies are hypothesis‐generating studies, and they can be further divided into descriptive and analytic. Descriptive observational studies provide a description of the exposure and/or the outcome, and analytic observational studies provide a measurement of the association between the exposure and the outcome. Experimental studies, on the other hand, are hypothesis testing studies. It involves an intervention that tests the association between the exposure and outcome. Each study design is different, and so it would be important to choose a design that would most appropriately answer the question in mind and provide the most valuable information. We will be reviewing each study design in detail (Figure  1 ).

Overview of clinical research study designs

Observational study designs

Observational studies ask the following questions: what, who, where and when. There are many study designs that fall under the umbrella of descriptive study designs, and they include, case reports, case series, ecologic study, cross‐sectional study, cohort study and case‐control study (Figure  2 ).

Classification of observational study designs

Case reports and case series

Every now and then during clinical practice, we come across a case that is atypical or ‘out of the norm’ type of clinical presentation. This atypical presentation is usually described as case reports which provides a detailed and comprehensive description of the case. 4 It is one of the earliest forms of research and provides an opportunity for the investigator to describe the observations that make a case unique. There are no inferences obtained and therefore cannot be generalized to the population which is a limitation. Most often than not, a series of case reports make a case series which is an atypical presentation found in a group of patients. This in turn poses the question for a new disease entity and further queries the investigator to look into mechanistic investigative opportunities to further explore. However, in a case series, the cases are not compared to subjects without the manifestations and therefore it cannot determine which factors in the description are unique to the new disease entity.

Ecologic study

Ecological studies are observational studies that provide a description of population group characteristics. That is, it describes characteristics to all individuals within a group. For example, Prentice et al 5 measured incidence of breast cancer and per capita intake of dietary fat, and found a correlation that higher per capita intake of dietary fat was associated with an increased incidence of breast cancer. But the study does not conclude specifically which subjects with breast cancer had a higher dietary intake of fat. Thus, one of the limitations with ecologic study designs is that the characteristics are attributed to the whole group and so the individual characteristics are unknown.

Cross‐sectional study

Cross‐sectional studies are study designs used to evaluate an association between an exposure and outcome at the same time. It can be classified under either descriptive or analytic, and therefore depends on the question being answered by the investigator. Since, cross‐sectional studies are designed to collect information at the same point of time, this provides an opportunity to measure prevalence of the exposure or the outcome. For example, a cross‐sectional study design was adopted to estimate the global need for palliative care for children based on representative sample of countries from all regions of the world and all World Bank income groups. 6 The limitation of cross‐sectional study design is that temporal association cannot be established as the information is collected at the same point of time. If a study involves a questionnaire, then the investigator can ask questions to onset of symptoms or risk factors in relation to onset of disease. This would help in obtaining a temporal sequence between the exposure and outcome. 7

Case‐control study

Case‐control studies are study designs that compare two groups, such as the subjects with disease (cases) to the subjects without disease (controls), and to look for differences in risk factors. 8 This study is used to study risk factors or etiologies for a disease, especially if the disease is rare. Thus, case‐control studies can also be hypothesis testing studies and therefore can suggest a causal relationship but cannot prove. It is less expensive and less time‐consuming than cohort studies (described in section “Cohort study”). An example of a case‐control study was performed in Pakistan evaluating the risk factors for neonatal tetanus. They retrospectively reviewed a defined cohort for cases with and without neonatal tetanus. 9 They found a strong association of the application of ghee (clarified butter) as a risk factor for neonatal tetanus. Although this suggests a causal relationship, cause cannot be proven by this methodology (Figure  3 ).

Case‐control study design

One of the limitations of case‐control studies is that they cannot estimate prevalence of a disease accurately as a proportion of cases and controls are studied at a time. Case‐control studies are also prone to biases such as recall bias, as the subjects are providing information based on their memory. Hence, the subjects with disease are likely to remember the presence of risk factors compared to the subjects without disease.

One of the aspects that is often overlooked is the selection of cases and controls. It is important to select the cases and controls appropriately to obtain a meaningful and scientifically sound conclusion and this can be achieved by implementing matching. Matching is defined by Gordis et al as ‘the process of selecting the controls so that they are similar to the cases in certain characteristics such as age, race, sex, socioeconomic status and occupation’ 7 This would help identify risk factors or probable etiologies that are not due to differences between the cases and controls.

Cohort study

Cohort studies are study designs that compare two groups, such as the subjects with exposure/risk factor to the subjects without exposure/risk factor, for differences in incidence of outcome/disease. Most often, cohort study designs are used to study outcome(s) from a single exposure/risk factor. Thus, cohort studies can also be hypothesis testing studies and can infer and interpret a causal relationship between an exposure and a proposed outcome, but cannot establish it (Figure  4 ).

Cohort study design

Cohort studies can be classified as prospective and retrospective. 7 Prospective cohort studies follow subjects from presence of risk factors/exposure to development of disease/outcome. This could take up to years before development of disease/outcome, and therefore is time consuming and expensive. On the other hand, retrospective cohort studies identify a population with and without the risk factor/exposure based on past records and then assess if they had developed the disease/outcome at the time of study. Thus, the study design for prospective and retrospective cohort studies are similar as we are comparing populations with and without exposure/risk factor to development of outcome/disease.

Cohort studies are typically chosen as a study design when the suspected exposure is known and rare, and the incidence of disease/outcome in the exposure group is suspected to be high. The choice between prospective and retrospective cohort study design would depend on the accuracy and reliability of the past records regarding the exposure/risk factor.

Some of the biases observed with cohort studies include selection bias and information bias. Some individuals who have the exposure may refuse to participate in the study or would be lost to follow‐up, and in those instances, it becomes difficult to interpret the association between an exposure and outcome. Also, if the information is inaccurate when past records are used to evaluate for exposure status, then again, the association between the exposure and outcome becomes difficult to interpret.

Case‐control studies based within a defined cohort

Case‐control studies based within a defined cohort is a form of study design that combines some of the features of a cohort study design and a case‐control study design. When a defined cohort is embedded in a case‐control study design, all the baseline information collected before the onset of disease like interviews, surveys, blood or urine specimens, then the cohort is followed onset of disease. One of the advantages of following the above design is that it eliminates recall bias as the information regarding risk factors is collected before onset of disease. Case‐control studies based within a defined cohort can be further classified into two types: Nested case‐control study and Case‐cohort study.

Nested case‐control study

A nested case‐control study consists of defining a cohort with suspected risk factors and assigning a control within a cohort to the subject who develops the disease. 10 Over a period, cases and controls are identified and followed as per the investigator's protocol. Hence, the case and control are matched on calendar time and length of follow‐up. When this study design is implemented, it is possible for the control that was selected early in the study to develop the disease and become a case in the latter part of the study.

Case‐cohort Study

A case‐cohort study is similar to a nested case‐control study except that there is a defined sub‐cohort which forms the groups of individuals without the disease (control), and the cases are not matched on calendar time or length of follow‐up with the control. 11 With these modifications, it is possible to compare different disease groups with the same sub‐cohort group of controls and eliminates matching between the case and control. However, these differences will need to be accounted during analysis of results.

Experimental study design

The basic concept of experimental study design is to study the effect of an intervention. In this study design, the risk factor/exposure of interest/treatment is controlled by the investigator. Therefore, these are hypothesis testing studies and can provide the most convincing demonstration of evidence for causality. As a result, the design of the study requires meticulous planning and resources to provide an accurate result.

The experimental study design can be classified into 2 groups, that is, controlled (with comparison) and uncontrolled (without comparison). 1 In the group without controls, the outcome is directly attributed to the treatment received in one group. This fails to prove if the outcome was truly due to the intervention implemented or due to chance. This can be avoided if a controlled study design is chosen which includes a group that does not receive the intervention (control group) and a group that receives the intervention (intervention/experiment group), and therefore provide a more accurate and valid conclusion.

Experimental study designs can be divided into 3 broad categories: clinical trial, community trial, field trial. The specifics of each study design are explained below (Figure  5 ).

Experimental study designs

Clinical trial

Clinical trials are also known as therapeutic trials, which involve subjects with disease and are placed in different treatment groups. It is considered a gold standard approach for epidemiological research. One of the earliest clinical trial studies was performed by James Lind et al in 1747 on sailors with scurvy. 12 Lind divided twelve scorbutic sailors into six groups of two. Each group received the same diet, in addition to a quart of cider (group 1), twenty‐five drops of elixir of vitriol which is sulfuric acid (group 2), two spoonfuls of vinegar (group 3), half a pint of seawater (group 4), two oranges and one lemon (group 5), and a spicy paste plus a drink of barley water (group 6). The group who ate two oranges and one lemon had shown the most sudden and visible clinical effects and were taken back at the end of 6 days as being fit for duty. During Lind's time, this was not accepted but was shown to have similar results when repeated 47 years later in an entire fleet of ships. Based on the above results, in 1795 lemon juice was made a required part of the diet of sailors. Thus, clinical trials can be used to evaluate new therapies, such as new drug or new indication, new drug combination, new surgical procedure or device, new dosing schedule or mode of administration, or a new prevention therapy.

While designing a clinical trial, it is important to select the population that is best representative of the general population. Therefore, the results obtained from the study can be generalized to the population from which the sample population was selected. It is also as important to select appropriate endpoints while designing a trial. Endpoints need to be well‐defined, reproducible, clinically relevant and achievable. The types of endpoints include continuous, ordinal, rates and time‐to‐event, and it is typically classified as primary, secondary or tertiary. 2 An ideal endpoint is a purely clinical outcome, for example, cure/survival, and thus, the clinical trials will become very long and expensive trials. Therefore, surrogate endpoints are used that are biologically related to the ideal endpoint. Surrogate endpoints need to be reproducible, easily measured, related to the clinical outcome, affected by treatment and occurring earlier than clinical outcome. 2

Clinical trials are further divided into randomized clinical trial, non‐randomized clinical trial, cross‐over clinical trial and factorial clinical trial.

Randomized clinical trial

A randomized clinical trial is also known as parallel group randomized trials or randomized controlled trials. Randomized clinical trials involve randomizing subjects with similar characteristics to two groups (or multiple groups): the group that receives the intervention/experimental therapy and the other group that received the placebo (or standard of care). 13 This is typically performed by using a computer software, manually or by other methods. Hence, we can measure the outcomes and efficacy of the intervention/experimental therapy being studied without bias as subjects have been randomized to their respective groups with similar baseline characteristics. This type of study design is considered gold standard for epidemiological research. However, this study design is generally not applicable to rare and serious disease process as it would unethical to treat that group with a placebo. Please see section “Randomization” for detailed explanation regarding randomization and placebo.

Non‐randomized clinical trial

A non‐randomized clinical trial involves an approach to selecting controls without randomization. With this type of study design a pattern is usually adopted, such as, selection of subjects and controls on certain days of the week. Depending on the approach adopted, the selection of subjects becomes predictable and therefore, there is bias with regards to selection of subjects and controls that would question the validity of the results obtained.

Historically controlled studies can be considered as a subtype of non‐randomized clinical trial. In this study design subtype, the source of controls is usually adopted from the past, such as from medical records and published literature. 1 The advantages of this study design include being cost‐effective, time saving and easily accessible. However, since this design depends on already collected data from different sources, the information obtained may not be accurate, reliable, lack uniformity and/or completeness as well. Though historically controlled studies maybe easier to conduct, the disadvantages will need to be taken into account while designing a study.

Cross‐over clinical trial

In cross‐over clinical trial study design, there are two groups who undergoes the same intervention/experiment at different time periods of the study. That is, each group serves as a control while the other group is undergoing the intervention/experiment. 14 Depending on the intervention/experiment, a ‘washout’ period is recommended. This would help eliminate residuals effects of the intervention/experiment when the experiment group transitions to be the control group. Hence, the outcomes of the intervention/experiment will need to be reversible as this type of study design would not be possible if the subject is undergoing a surgical procedure.

Factorial trial

A factorial trial study design is adopted when the researcher wishes to test two different drugs with independent effects on the same population. Typically, the population is divided into 4 groups, the first with drug A, the second with drug B, the third with drug A and B, and the fourth with neither drug A nor drug B. The outcomes for drug A are compared to those on drug A, drug A and B and to those who were on drug B and neither drug A nor drug B. 15 The advantages of this study design that it saves time and helps to study two different drugs on the same study population at the same time. However, this study design would not be applicable if either of the drugs or interventions overlaps with each other on modes of action or effects, as the results obtained would not attribute to a particular drug or intervention.

Community trial

Community trials are also known as cluster‐randomized trials, involve groups of individuals with and without disease who are assigned to different intervention/experiment groups. Hence, groups of individuals from a certain area, such as a town or city, or a certain group such as school or college, will undergo the same intervention/experiment. 16 Hence, the results will be obtained at a larger scale; however, will not be able to account for inter‐individual and intra‐individual variability.

Field trial

Field trials are also known as preventive or prophylactic trials, and the subjects without the disease are placed in different preventive intervention groups. 16 One of the hypothetical examples for a field trial would be to randomly assign to groups of a healthy population and to provide an intervention to a group such as a vitamin and following through to measure certain outcomes. Hence, the subjects are monitored over a period of time for occurrence of a particular disease process.

Overview of methodologies used within a study design

Randomization.

Randomization is a well‐established methodology adopted in research to prevent bias due to subject selection, which may impact the result of the intervention/experiment being studied. It is one of the fundamental principles of an experimental study designs and ensures scientific validity. It provides a way to avoid predicting which subjects are assigned to a certain group and therefore, prevent bias on the final results due to subject selection. This also ensures comparability between groups as most baseline characteristics are similar prior to randomization and therefore helps to interpret the results regarding the intervention/experiment group without bias.

There are various ways to randomize and it can be as simple as a ‘flip of a coin’ to use computer software and statistical methods. To better describe randomization, there are three types of randomization: simple randomization, block randomization and stratified randomization.

Simple randomization

In simple randomization, the subjects are randomly allocated to experiment/intervention groups based on a constant probability. That is, if there are two groups A and B, the subject has a 0.5 probability of being allocated to either group. This can be performed in multiple ways, and one of which being as simple as a ‘flip of a coin’ to using random tables or numbers. 17 The advantage of using this methodology is that it eliminates selection bias. However, the disadvantage with this methodology is that an imbalance in the number allocated to each group as well as the prognostic factors between groups. Hence, it is more challenging in studies with a small sample size.

Block randomization

In block randomization, the subjects of similar characteristics are classified into blocks. The aim of block randomization is to balance the number of subjects allocated to each experiment/intervention group. For example, let's assume that there are four subjects in each block, and two of the four subjects in each block will be randomly allotted to each group. Therefore, there will be two subjects in one group and two subjects in the other group. 17 The disadvantage with this methodology is that there is still a component of predictability in the selection of subjects and the randomization of prognostic factors is not performed. However, it helps to control the balance between the experiment/intervention groups.

Stratified randomization

In stratified randomization, the subjects are defined based on certain strata, which are covariates. 18 For example, prognostic factors like age can be considered as a covariate, and then the specified population can be randomized within each age group related to an experiment/intervention group. The advantage with this methodology is that it enables comparability between experiment/intervention groups and thus makes result analysis more efficient. But, with this methodology the covariates will need to be measured and determined before the randomization process. The sample size will help determine the number of strata that would need to be chosen for a study.

Blinding is a methodology adopted in a study design to intentionally not provide information related to the allocation of the groups to the subject participants, investigators and/or data analysts. 19 The purpose of blinding is to decrease influence associated with the knowledge of being in a particular group on the study result. There are 3 forms of blinding: single‐blinded, double‐blinded and triple‐blinded. 1 In single‐blinded studies, otherwise called as open‐label studies, the subject participants are not revealed which group that they have been allocated to. However, the investigator and data analyst will be aware of the allocation of the groups. In double‐blinded studies, both the study participants and the investigator will be unaware of the group to which they were allocated to. Double‐blinded studies are typically used in clinical trials to test the safety and efficacy of the drugs. In triple‐blinded studies, the subject participants, investigators and data analysts will not be aware of the group allocation. Thus, triple‐blinded studies are more difficult and expensive to design but the results obtained will exclude confounding effects from knowledge of group allocation.

Blinding is especially important in studies where subjective response are considered as outcomes. This is because certain responses can be modified based on the knowledge of the experiment group that they are in. For example, a group allocated in the non‐intervention group may not feel better as they are not getting the treatment, or an investigator may pay more attention to the group receiving treatment, and thereby potentially affecting the final results. However, certain treatments cannot be blinded such as surgeries or if the treatment group requires an assessment of the effect of intervention such as quitting smoking.

Placebo is defined in the Merriam‐Webster dictionary as ‘an inert or innocuous substance used especially in controlled experiments testing the efficacy of another substance (such as drug)’. 20 A placebo is typically used in a clinical research study to evaluate the safety and efficacy of a drug/intervention. This is especially useful if the outcome measured is subjective. In clinical drug trials, a placebo is typically a drug that resembles the drug to be tested in certain characteristics such as color, size, shape and taste, but without the active substance. This helps to measure effects of just taking the drug, such as pain relief, compared to the drug with the active substance. If the effect is positive, for example, improvement in mood/pain, then it is called placebo effect. If the effect is negative, for example, worsening of mood/pain, then it is called nocebo effect. 21

The ethics of placebo‐controlled studies is complex and remains a debate in the medical research community. According to the Declaration of Helsinki on the use of placebo released in October 2013, “The benefits, risks, burdens and effectiveness of a new intervention must be tested against those of the best proven intervention(s), except in the following circumstances:

Where no proven intervention exists, the use of placebo, or no intervention, is acceptable; or

Where for compelling and scientifically sound methodological reasons the use of any intervention less effective than the best proven one, the use of placebo, or no intervention is necessary to determine the efficacy or safety of an intervention and the patients who receive any intervention less effective than the best proven one, placebo, or no intervention will not be subject to additional risks of serious or irreversible harm as a result of not receiving the best proven intervention.

Extreme care must be taken to avoid abuse of this option”. 22

Hence, while designing a research study, both the scientific validity and ethical aspects of the study will need to be thoroughly evaluated.

Bias has been defined as “any systematic error in the design, conduct or analysis of a study that results in a mistaken estimate of an exposure's effect on the risk of disease”. 23 There are multiple types of biases and so, in this review we will focus on the following types: selection bias, information bias and observer bias. Selection bias is when a systematic error is committed while selecting subjects for the study. Selection bias will affect the external validity of the study if the study subjects are not representative of the population being studied and therefore, the results of the study will not be generalizable. Selection bias will affect the internal validity of the study if the selection of study subjects in each group is influenced by certain factors, such as, based on the treatment of the group assigned. One of the ways to decrease selection bias is to select the study population that would representative of the population being studied, or to randomize (discussed in section “Randomization”).

Information bias is when a systematic error is committed while obtaining data from the study subjects. This can be in the form of recall bias when subject is required to remember certain events from the past. Typically, subjects with the disease tend to remember certain events compared to subjects without the disease. Observer bias is a systematic error when the study investigator is influenced by the certain characteristics of the group, that is, an investigator may pay closer attention to the group receiving the treatment versus the group not receiving the treatment. This may influence the results of the study. One of the ways to decrease observer bias is to use blinding (discussed in section “Blinding”).

Thus, while designing a study it is important to take measure to limit bias as much as possible so that the scientific validity of the study results is preserved to its maximum.

Overview of drug development in the United States of America

Now that we have reviewed the various clinical designs, clinical trials form a major part in development of a drug. In the United States, the Food and Drug Administration (FDA) plays an important role in getting a drug approved for clinical use. It includes a robust process that involves four different phases before a drug can be made available to the public. Phase I is conducted to determine a safe dose. The study subjects consist of normal volunteers and/or subjects with disease of interest, and the sample size is typically small and not more than 30 subjects. The primary endpoint consists of toxicity and adverse events. Phase II is conducted to evaluate of safety of dose selected in Phase I, to collect preliminary information on efficacy and to determine factors to plan a randomized controlled trial. The study subjects consist of subjects with disease of interest and the sample size is also small but more that Phase I (40–100 subjects). The primary endpoint is the measure of response. Phase III is conducted as a definitive trial to prove efficacy and establish safety of a drug. Phase III studies are randomized controlled trials and depending on the drug being studied, it can be placebo‐controlled, equivalence, superiority or non‐inferiority trials. The study subjects consist of subjects with disease of interest, and the sample size is typically large but no larger than 300 to 3000. Phase IV is performed after a drug is approved by the FDA and it is also called the post‐marketing clinical trial. This phase is conducted to evaluate new indications, to determine safety and efficacy in long‐term follow‐up and new dosing regimens. This phase helps to detect rare adverse events that would not be picked up during phase III studies and decrease in the delay in the release of the drug in the market. Hence, this phase depends heavily on voluntary reporting of side effects and/or adverse events by physicians, non‐physicians or drug companies. 2

We have discussed various clinical research study designs in this comprehensive review. Though there are various designs available, one must consider various ethical aspects of the study. Hence, each study will require thorough review of the protocol by the institutional review board before approval and implementation.

CONFLICT OF INTEREST

Chidambaram AG, Josephson M. Clinical research study designs: The essentials . Pediatr Invest . 2019; 3 :245‐252. 10.1002/ped4.12166 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]

• Experimental Research Designs: Types, Examples & Methods

Experimental research is the most familiar type of research design for individuals in the physical sciences and a host of other fields. This is mainly because experimental research is a classical scientific experiment, similar to those performed in high school science classes.

Imagine taking 2 samples of the same plant and exposing one of them to sunlight, while the other is kept away from sunlight. Let the plant exposed to sunlight be called sample A, while the latter is called sample B.

If after the duration of the research, we find out that sample A grows and sample B dies, even though they are both regularly wetted and given the same treatment. Therefore, we can conclude that sunlight will aid growth in all similar plants.

What is Experimental Research?

Experimental research is a scientific approach to research, where one or more independent variables are manipulated and applied to one or more dependent variables to measure their effect on the latter. The effect of the independent variables on the dependent variables is usually observed and recorded over some time, to aid researchers in drawing a reasonable conclusion regarding the relationship between these 2 variable types.

The experimental research method is widely used in physical and social sciences, psychology, and education. It is based on the comparison between two or more groups with a straightforward logic, which may, however, be difficult to execute.

Mostly related to a laboratory test procedure, experimental research designs involve collecting quantitative data and performing statistical analysis on them during research. Therefore, making it an example of quantitative research method .

What are The Types of Experimental Research Design?

The types of experimental research design are determined by the way the researcher assigns subjects to different conditions and groups. They are of 3 types, namely; pre-experimental, quasi-experimental, and true experimental research.

Pre-experimental Research Design

In pre-experimental research design, either a group or various dependent groups are observed for the effect of the application of an independent variable which is presumed to cause change. It is the simplest form of experimental research design and is treated with no control group.

Although very practical, experimental research is lacking in several areas of the true-experimental criteria. The pre-experimental research design is further divided into three types

• One-shot Case Study Research Design

In this type of experimental study, only one dependent group or variable is considered. The study is carried out after some treatment which was presumed to cause change, making it a posttest study.

• One-group Pretest-posttest Research Design: 

This research design combines both posttest and pretest study by carrying out a test on a single group before the treatment is administered and after the treatment is administered. With the former being administered at the beginning of treatment and later at the end.

• Static-group Comparison: 

In a static-group comparison study, 2 or more groups are placed under observation, where only one of the groups is subjected to some treatment while the other groups are held static. All the groups are post-tested, and the observed differences between the groups are assumed to be a result of the treatment.

Quasi-experimental Research Design

  The word “quasi” means partial, half, or pseudo. Therefore, the quasi-experimental research bearing a resemblance to the true experimental research, but not the same.  In quasi-experiments, the participants are not randomly assigned, and as such, they are used in settings where randomization is difficult or impossible.

 This is very common in educational research, where administrators are unwilling to allow the random selection of students for experimental samples.

Some examples of quasi-experimental research design include; the time series, no equivalent control group design, and the counterbalanced design.

True Experimental Research Design

The true experimental research design relies on statistical analysis to approve or disprove a hypothesis. It is the most accurate type of experimental design and may be carried out with or without a pretest on at least 2 randomly assigned dependent subjects.

The true experimental research design must contain a control group, a variable that can be manipulated by the researcher, and the distribution must be random. The classification of true experimental design include:

• The posttest-only Control Group Design: In this design, subjects are randomly selected and assigned to the 2 groups (control and experimental), and only the experimental group is treated. After close observation, both groups are post-tested, and a conclusion is drawn from the difference between these groups.
• The pretest-posttest Control Group Design: For this control group design, subjects are randomly assigned to the 2 groups, both are presented, but only the experimental group is treated. After close observation, both groups are post-tested to measure the degree of change in each group.
• Solomon four-group Design: This is the combination of the pretest-only and the pretest-posttest control groups. In this case, the randomly selected subjects are placed into 4 groups.

The first two of these groups are tested using the posttest-only method, while the other two are tested using the pretest-posttest method.

Examples of Experimental Research

Experimental research examples are different, depending on the type of experimental research design that is being considered. The most basic example of experimental research is laboratory experiments, which may differ in nature depending on the subject of research.

Administering Exams After The End of Semester

During the semester, students in a class are lectured on particular courses and an exam is administered at the end of the semester. In this case, the students are the subjects or dependent variables while the lectures are the independent variables treated on the subjects.

Only one group of carefully selected subjects are considered in this research, making it a pre-experimental research design example. We will also notice that tests are only carried out at the end of the semester, and not at the beginning.

Further making it easy for us to conclude that it is a one-shot case study research. 

Employee Skill Evaluation

Before employing a job seeker, organizations conduct tests that are used to screen out less qualified candidates from the pool of qualified applicants. This way, organizations can determine an employee’s skill set at the point of employment.

In the course of employment, organizations also carry out employee training to improve employee productivity and generally grow the organization. Further evaluation is carried out at the end of each training to test the impact of the training on employee skills, and test for improvement.

Here, the subject is the employee, while the treatment is the training conducted. This is a pretest-posttest control group experimental research example.

Evaluation of Teaching Method

Let us consider an academic institution that wants to evaluate the teaching method of 2 teachers to determine which is best. Imagine a case whereby the students assigned to each teacher is carefully selected probably due to personal request by parents or due to stubbornness and smartness.

This is a no equivalent group design example because the samples are not equal. By evaluating the effectiveness of each teacher’s teaching method this way, we may conclude after a post-test has been carried out.

However, this may be influenced by factors like the natural sweetness of a student. For example, a very smart student will grab more easily than his or her peers irrespective of the method of teaching.

What are the Characteristics of Experimental Research?  

Experimental research contains dependent, independent and extraneous variables. The dependent variables are the variables being treated or manipulated and are sometimes called the subject of the research.

The independent variables are the experimental treatment being exerted on the dependent variables. Extraneous variables, on the other hand, are other factors affecting the experiment that may also contribute to the change.

The setting is where the experiment is carried out. Many experiments are carried out in the laboratory, where control can be exerted on the extraneous variables, thereby eliminating them.

Other experiments are carried out in a less controllable setting. The choice of setting used in research depends on the nature of the experiment being carried out.

• Multivariable

Experimental research may include multiple independent variables, e.g. time, skills, test scores, etc.

Why Use Experimental Research Design?  

Experimental research design can be majorly used in physical sciences, social sciences, education, and psychology. It is used to make predictions and draw conclusions on a subject matter. 

Some uses of experimental research design are highlighted below.

• Medicine: Experimental research is used to provide the proper treatment for diseases. In most cases, rather than directly using patients as the research subject, researchers take a sample of the bacteria from the patient’s body and are treated with the developed antibacterial

The changes observed during this period are recorded and evaluated to determine its effectiveness. This process can be carried out using different experimental research methods.

• Education: Asides from science subjects like Chemistry and Physics which involves teaching students how to perform experimental research, it can also be used in improving the standard of an academic institution. This includes testing students’ knowledge on different topics, coming up with better teaching methods, and the implementation of other programs that will aid student learning.
• Human Behavior: Social scientists are the ones who mostly use experimental research to test human behaviour. For example, consider 2 people randomly chosen to be the subject of the social interaction research where one person is placed in a room without human interaction for 1 year.

The other person is placed in a room with a few other people, enjoying human interaction. There will be a difference in their behaviour at the end of the experiment.

• UI/UX: During the product development phase, one of the major aims of the product team is to create a great user experience with the product. Therefore, before launching the final product design, potential are brought in to interact with the product.

For example, when finding it difficult to choose how to position a button or feature on the app interface, a random sample of product testers are allowed to test the 2 samples and how the button positioning influences the user interaction is recorded.

What are the Disadvantages of Experimental Research?  

• It is highly prone to human error due to its dependency on variable control which may not be properly implemented. These errors could eliminate the validity of the experiment and the research being conducted.
• Exerting control of extraneous variables may create unrealistic situations. Eliminating real-life variables will result in inaccurate conclusions. This may also result in researchers controlling the variables to suit his or her personal preferences.
• It is a time-consuming process. So much time is spent on testing dependent variables and waiting for the effect of the manipulation of dependent variables to manifest.
• It is expensive.
• It is very risky and may have ethical complications that cannot be ignored. This is common in medical research, where failed trials may lead to a patient’s death or a deteriorating health condition.
• Experimental research results are not descriptive.
• Response bias can also be supplied by the subject of the conversation.
• Human responses in experimental research can be difficult to measure.

What are the Data Collection Methods in Experimental Research?  

Data collection methods in experimental research are the different ways in which data can be collected for experimental research. They are used in different cases, depending on the type of research being carried out.

1. Observational Study

This type of study is carried out over a long period. It measures and observes the variables of interest without changing existing conditions.

When researching the effect of social interaction on human behavior, the subjects who are placed in 2 different environments are observed throughout the research. No matter the kind of absurd behavior that is exhibited by the subject during this period, its condition will not be changed.

This may be a very risky thing to do in medical cases because it may lead to death or worse medical conditions.

2. Simulations

This procedure uses mathematical, physical, or computer models to replicate a real-life process or situation. It is frequently used when the actual situation is too expensive, dangerous, or impractical to replicate in real life.

This method is commonly used in engineering and operational research for learning purposes and sometimes as a tool to estimate possible outcomes of real research. Some common situation software are Simulink, MATLAB, and Simul8.

Not all kinds of experimental research can be carried out using simulation as a data collection tool . It is very impractical for a lot of laboratory-based research that involves chemical processes.

A survey is a tool used to gather relevant data about the characteristics of a population and is one of the most common data collection tools. A survey consists of a group of questions prepared by the researcher, to be answered by the research subject.

Surveys can be shared with the respondents both physically and electronically. When collecting data through surveys, the kind of data collected depends on the respondent, and researchers have limited control over it.

Formplus is the best tool for collecting experimental data using survey s. It has relevant features that will aid the data collection process and can also be used in other aspects of experimental research.

Differences between Experimental and Non-Experimental Research 

1. In experimental research, the researcher can control and manipulate the environment of the research, including the predictor variable which can be changed. On the other hand, non-experimental research cannot be controlled or manipulated by the researcher at will.

This is because it takes place in a real-life setting, where extraneous variables cannot be eliminated. Therefore, it is more difficult to conclude non-experimental studies, even though they are much more flexible and allow for a greater range of study fields.

2. The relationship between cause and effect cannot be established in non-experimental research, while it can be established in experimental research. This may be because many extraneous variables also influence the changes in the research subject, making it difficult to point at a particular variable as the cause of a particular change

3. Independent variables are not introduced, withdrawn, or manipulated in non-experimental designs, but the same may not be said about experimental research.

Experimental Research vs. Alternatives and When to Use Them

1. experimental research vs causal comparative.

Experimental research enables you to control variables and identify how the independent variable affects the dependent variable. Causal-comparative find out the cause-and-effect relationship between the variables by comparing already existing groups that are affected differently by the independent variable.

For example, in an experiment to see how K-12 education affects children and teenager development. An experimental research would split the children into groups, some would get formal K-12 education, while others won’t. This is not ethically right because every child has the right to education. So, what we do instead would be to compare already existing groups of children who are getting formal education with those who due to some circumstances can not.

Pros and Cons of Experimental vs Causal-Comparative Research

• Causal-Comparative:   Strengths:  More realistic than experiments, can be conducted in real-world settings.  Weaknesses:  Establishing causality can be weaker due to the lack of manipulation.

2. Experimental Research vs Correlational Research

When experimenting, you are trying to establish a cause-and-effect relationship between different variables. For example, you are trying to establish the effect of heat on water, the temperature keeps changing (independent variable) and you see how it affects the water (dependent variable).

For correlational research, you are not necessarily interested in the why or the cause-and-effect relationship between the variables, you are focusing on the relationship. Using the same water and temperature example, you are only interested in the fact that they change, you are not investigating which of the variables or other variables causes them to change.

Pros and Cons of Experimental vs Correlational Research

3. experimental research vs descriptive research.

With experimental research, you alter the independent variable to see how it affects the dependent variable, but with descriptive research you are simply studying the characteristics of the variable you are studying.

So, in an experiment to see how blown glass reacts to temperature, experimental research would keep altering the temperature to varying levels of high and low to see how it affects the dependent variable (glass). But descriptive research would investigate the glass properties.

Pros and Cons of Experimental vs Descriptive Research

4. experimental research vs action research.

Experimental research tests for causal relationships by focusing on one independent variable vs the dependent variable and keeps other variables constant. So, you are testing hypotheses and using the information from the research to contribute to knowledge.

However, with action research, you are using a real-world setting which means you are not controlling variables. You are also performing the research to solve actual problems and improve already established practices.

For example, if you are testing for how long commutes affect workers’ productivity. With experimental research, you would vary the length of commute to see how the time affects work. But with action research, you would account for other factors such as weather, commute route, nutrition, etc. Also, experimental research helps know the relationship between commute time and productivity, while action research helps you look for ways to improve productivity

Pros and Cons of Experimental vs Action Research

Conclusion  .

Experimental research designs are often considered to be the standard in research designs. This is partly due to the common misconception that research is equivalent to scientific experiments—a component of experimental research design.

In this research design, one or more subjects or dependent variables are randomly assigned to different treatments (i.e. independent variables manipulated by the researcher) and the results are observed to conclude. One of the uniqueness of experimental research is in its ability to control the effect of extraneous variables.

Experimental research is suitable for research whose goal is to examine cause-effect relationships, e.g. explanatory research. It can be conducted in the laboratory or field settings, depending on the aim of the research that is being carried out. 

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Experimental Research Design — 6 mistakes you should never make!

Since school days’ students perform scientific experiments that provide results that define and prove the laws and theorems in science. These experiments are laid on a strong foundation of experimental research designs.

An experimental research design helps researchers execute their research objectives with more clarity and transparency.

In this article, we will not only discuss the key aspects of experimental research designs but also the issues to avoid and problems to resolve while designing your research study.

Table of Contents

What Is Experimental Research Design?

Experimental research design is a framework of protocols and procedures created to conduct experimental research with a scientific approach using two sets of variables. Herein, the first set of variables acts as a constant, used to measure the differences of the second set. The best example of experimental research methods is quantitative research .

Experimental research helps a researcher gather the necessary data for making better research decisions and determining the facts of a research study.

When Can a Researcher Conduct Experimental Research?

A researcher can conduct experimental research in the following situations —

• When time is an important factor in establishing a relationship between the cause and effect.
• When there is an invariable or never-changing behavior between the cause and effect.
• Finally, when the researcher wishes to understand the importance of the cause and effect.

Importance of Experimental Research Design

To publish significant results, choosing a quality research design forms the foundation to build the research study. Moreover, effective research design helps establish quality decision-making procedures, structures the research to lead to easier data analysis, and addresses the main research question. Therefore, it is essential to cater undivided attention and time to create an experimental research design before beginning the practical experiment.

By creating a research design, a researcher is also giving oneself time to organize the research, set up relevant boundaries for the study, and increase the reliability of the results. Through all these efforts, one could also avoid inconclusive results. If any part of the research design is flawed, it will reflect on the quality of the results derived.

Types of Experimental Research Designs

Based on the methods used to collect data in experimental studies, the experimental research designs are of three primary types:

1. Pre-experimental Research Design

A research study could conduct pre-experimental research design when a group or many groups are under observation after implementing factors of cause and effect of the research. The pre-experimental design will help researchers understand whether further investigation is necessary for the groups under observation.

Pre-experimental research is of three types —

• One-shot Case Study Research Design
• One-group Pretest-posttest Research Design
• Static-group Comparison

2. True Experimental Research Design

A true experimental research design relies on statistical analysis to prove or disprove a researcher’s hypothesis. It is one of the most accurate forms of research because it provides specific scientific evidence. Furthermore, out of all the types of experimental designs, only a true experimental design can establish a cause-effect relationship within a group. However, in a true experiment, a researcher must satisfy these three factors —

• There is a control group that is not subjected to changes and an experimental group that will experience the changed variables
• A variable that can be manipulated by the researcher
• Random distribution of the variables

This type of experimental research is commonly observed in the physical sciences.

3. Quasi-experimental Research Design

The word “Quasi” means similarity. A quasi-experimental design is similar to a true experimental design. However, the difference between the two is the assignment of the control group. In this research design, an independent variable is manipulated, but the participants of a group are not randomly assigned. This type of research design is used in field settings where random assignment is either irrelevant or not required.

The classification of the research subjects, conditions, or groups determines the type of research design to be used.

Advantages of Experimental Research

Experimental research allows you to test your idea in a controlled environment before taking the research to clinical trials. Moreover, it provides the best method to test your theory because of the following advantages:

• Researchers have firm control over variables to obtain results.
• The subject does not impact the effectiveness of experimental research. Anyone can implement it for research purposes.
• The results are specific.
• Post results analysis, research findings from the same dataset can be repurposed for similar research ideas.
• Researchers can identify the cause and effect of the hypothesis and further analyze this relationship to determine in-depth ideas.
• Experimental research makes an ideal starting point. The collected data could be used as a foundation to build new research ideas for further studies.

6 Mistakes to Avoid While Designing Your Research

There is no order to this list, and any one of these issues can seriously compromise the quality of your research. You could refer to the list as a checklist of what to avoid while designing your research.

1. Invalid Theoretical Framework

Usually, researchers miss out on checking if their hypothesis is logical to be tested. If your research design does not have basic assumptions or postulates, then it is fundamentally flawed and you need to rework on your research framework.

2. Inadequate Literature Study

Without a comprehensive research literature review , it is difficult to identify and fill the knowledge and information gaps. Furthermore, you need to clearly state how your research will contribute to the research field, either by adding value to the pertinent literature or challenging previous findings and assumptions.

3. Insufficient or Incorrect Statistical Analysis

Statistical results are one of the most trusted scientific evidence. The ultimate goal of a research experiment is to gain valid and sustainable evidence. Therefore, incorrect statistical analysis could affect the quality of any quantitative research.

4. Undefined Research Problem

This is one of the most basic aspects of research design. The research problem statement must be clear and to do that, you must set the framework for the development of research questions that address the core problems.

5. Research Limitations

Every study has some type of limitations . You should anticipate and incorporate those limitations into your conclusion, as well as the basic research design. Include a statement in your manuscript about any perceived limitations, and how you considered them while designing your experiment and drawing the conclusion.

6. Ethical Implications

The most important yet less talked about topic is the ethical issue. Your research design must include ways to minimize any risk for your participants and also address the research problem or question at hand. If you cannot manage the ethical norms along with your research study, your research objectives and validity could be questioned.

Experimental Research Design Example

In an experimental design, a researcher gathers plant samples and then randomly assigns half the samples to photosynthesize in sunlight and the other half to be kept in a dark box without sunlight, while controlling all the other variables (nutrients, water, soil, etc.)

By comparing their outcomes in biochemical tests, the researcher can confirm that the changes in the plants were due to the sunlight and not the other variables.

Experimental research is often the final form of a study conducted in the research process which is considered to provide conclusive and specific results. But it is not meant for every research. It involves a lot of resources, time, and money and is not easy to conduct, unless a foundation of research is built. Yet it is widely used in research institutes and commercial industries, for its most conclusive results in the scientific approach.

Have you worked on research designs? How was your experience creating an experimental design? What difficulties did you face? Do write to us or comment below and share your insights on experimental research designs!

Frequently Asked Questions

Randomization is important in an experimental research because it ensures unbiased results of the experiment. It also measures the cause-effect relationship on a particular group of interest.

Experimental research design lay the foundation of a research and structures the research to establish quality decision making process.

There are 3 types of experimental research designs. These are pre-experimental research design, true experimental research design, and quasi experimental research design.

The difference between an experimental and a quasi-experimental design are: 1. The assignment of the control group in quasi experimental research is non-random, unlike true experimental design, which is randomly assigned. 2. Experimental research group always has a control group; on the other hand, it may not be always present in quasi experimental research.

Experimental research establishes a cause-effect relationship by testing a theory or hypothesis using experimental groups or control variables. In contrast, descriptive research describes a study or a topic by defining the variables under it and answering the questions related to the same.

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An introduction to different types of study design

Posted on 6th April 2021 by Hadi Abbas

Study designs are the set of methods and procedures used to collect and analyze data in a study.

Broadly speaking, there are 2 types of study designs: descriptive studies and analytical studies.

Descriptive studies

• Describes specific characteristics in a population of interest
• The most common forms are case reports and case series
• In a case report, we discuss our experience with the patient’s symptoms, signs, diagnosis, and treatment
• In a case series, several patients with similar experiences are grouped.

Analytical Studies

Analytical studies are of 2 types: observational and experimental.

Observational studies are studies that we conduct without any intervention or experiment. In those studies, we purely observe the outcomes.  On the other hand, in experimental studies, we conduct experiments and interventions.

Observational studies

Observational studies include many subtypes. Below, I will discuss the most common designs.

Cross-sectional study:

• This design is transverse where we take a specific sample at a specific time without any follow-up
• It allows us to calculate the frequency of disease ( p revalence ) or the frequency of a risk factor
• This design is easy to conduct
• For example – if we want to know the prevalence of migraine in a population, we can conduct a cross-sectional study whereby we take a sample from the population and calculate the number of patients with migraine headaches.

Cohort study:

• We conduct this study by comparing two samples from the population: one sample with a risk factor while the other lacks this risk factor
• It shows us the risk of developing the disease in individuals with the risk factor compared to those without the risk factor ( RR = relative risk )
• Prospective : we follow the individuals in the future to know who will develop the disease
• Retrospective : we look to the past to know who developed the disease (e.g. using medical records)
• This design is the strongest among the observational studies
• For example – to find out the relative risk of developing chronic obstructive pulmonary disease (COPD) among smokers, we take a sample including smokers and non-smokers. Then, we calculate the number of individuals with COPD among both.

Case-Control Study:

• We conduct this study by comparing 2 groups: one group with the disease (cases) and another group without the disease (controls)
• This design is always retrospective
•  We aim to find out the odds of having a risk factor or an exposure if an individual has a specific disease (Odds ratio)
•  Relatively easy to conduct
• For example – we want to study the odds of being a smoker among hypertensive patients compared to normotensive ones. To do so, we choose a group of patients diagnosed with hypertension and another group that serves as the control (normal blood pressure). Then we study their smoking history to find out if there is a correlation.

Experimental Studies

• Also known as interventional studies
• Can involve animals and humans
• Pre-clinical trials involve animals
• Clinical trials are experimental studies involving humans
• In clinical trials, we study the effect of an intervention compared to another intervention or placebo. As an example, I have listed the four phases of a drug trial:

I:  We aim to assess the safety of the drug ( is it safe ? )

II: We aim to assess the efficacy of the drug ( does it work ? )

III: We want to know if this drug is better than the old treatment ( is it better ? )

IV: We follow-up to detect long-term side effects ( can it stay in the market ? )

• In randomized controlled trials, one group of participants receives the control, while the other receives the tested drug/intervention. Those studies are the best way to evaluate the efficacy of a treatment.

Finally, the figure below will help you with your understanding of different types of study designs.

References (pdf)

You may also be interested in the following blogs for further reading:

An introduction to randomized controlled trials

Case-control and cohort studies: a brief overview

Cohort studies: prospective and retrospective designs

Prevalence vs Incidence: what is the difference?

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No Comments on An introduction to different types of study design

you are amazing one!! if I get you I’m working with you! I’m student from Ethiopian higher education. health sciences student

Very informative and easy understandable

You are my kind of doctor. Do not lose sight of your objective.

Wow very erll explained and easy to understand

I’m Khamisu Habibu community health officer student from Abubakar Tafawa Balewa university teaching hospital Bauchi, Nigeria, I really appreciate your write up and you have make it clear for the learner. thank you

well understood,thank you so much

Well understood…thanks

Simply explained. Thank You.

Thanks a lot for this nice informative article which help me to understand different study designs that I felt difficult before

That’s lovely to hear, Mona, thank you for letting the author know how useful this was. If there are any other particular topics you think would be useful to you, and are not already on the website, please do let us know.

it is very informative and useful.

thank you statistician

Fabulous to hear, thank you John.

Thanks for this information

Thanks so much for this information….I have clearly known the types of study design Thanks

That’s so good to hear, Mirembe, thank you for letting the author know.

Very helpful article!! U have simplified everything for easy understanding

I’m a health science major currently taking statistics for health care workers…this is a challenging class…thanks for the simified feedback.

That’s good to hear this has helped you. Hopefully you will find some of the other blogs useful too. If you see any topics that are missing from the website, please do let us know!

Hello. I liked your presentation, the fact that you ranked them clearly is very helpful to understand for people like me who is a novelist researcher. However, I was expecting to read much more about the Experimental studies. So please direct me if you already have or will one day. Thank you

Dear Ay. My sincere apologies for not responding to your comment sooner. You may find it useful to filter the blogs by the topic of ‘Study design and research methods’ – here is a link to that filter: https://s4be.cochrane.org/blog/topic/study-design/ This will cover more detail about experimental studies. Or have a look on our library page for further resources there – you’ll find that on the ‘Resources’ drop down from the home page.

However, if there are specific things you feel you would like to learn about experimental studies, that are missing from the website, it would be great if you could let me know too. Thank you, and best of luck. Emma

Great job Mr Hadi. I advise you to prepare and study for the Australian Medical Board Exams as soon as you finish your undergrad study in Lebanon. Good luck and hope we can meet sometime in the future. Regards ;)

You have give a good explaination of what am looking for. However, references am not sure of where to get them from.

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FAQs About Experimental Research Papers (APA)

What is a research paper? 

A researcher uses a research paper to explain how they conducted a research study to answer a question or test a hypothesis. They explain why they conducted the study, the research question or hypothesis they tested, how they conducted the study, the results of their study, and the implications of these results. 

What is the purpose of an experimental research paper? 

A research paper is intended to inform others about advancement in a particular field of study. The researcher who wrote the paper identified a gap in the research in a field of study and used their research to help fill this gap. The researcher uses their paper to inform others about the knowledge that the results of their study contribute. 

What sections are included in an experimental research paper?

A typical research paper contains a Title Page, Abstract, Introduction, Methods, Results, Discussion, and References section. Some also contain a Table and Figures section and Appendix section. 

What citation style is used for experimental research papers? 

APA (American Psychological Association) style is most commonly used for research papers. 

Structure Of Experimental Research Papers (APA)

• Answers the question of “What is this paper about and who wrote it?”
• Located on the first page of the paper 
• The author’s note acknowledges any support that the authors received from others
• A student paper also includes the course number and name, instructor’s name, and assignment due date
• Contains a title that summarizes the purpose and content of the research study and engages the audience 
• No longer than 250 words
• Summarizes important background information, the research questions and/or hypothesis, methods, key findings, and implications of the findings
• Explains what the topic of the research is and why the topic is worth studying
• Summarizes and discusses prior research conducted on the topic 
• Identifies unresolved issues and gaps in past research that the current research will address
• Ends with an overview of the current research study, including how the independent and dependent variables, the research questions or hypotheses, and the objective of the research 
• Explains how the research study was conducted 
• Typically includes 3 sections: Participants, Materials, and Procedure
• Includes characteristics of the subjects, how the subjects were selected and recruited, how their anonymity was protected, and what feedback was provided to the participants
• Describes any equipment, surveys, tests, questionnaires, informed consent forms, and observational techniques 
• Describes the independent and dependent variables, the type of research design, and how the data was collected
• Explains what results were found in the research study 
• Describes the data that was collected and the results of statistical tests 
• Explains the significance of the results 
• Accepts or denies the hypotheses 
• Details the implications of these findings 
• Addresses the limitations of the study and areas for future research 
• Includes all sources that were mentioned in the research study 
• Adheres to APA citation styles
• Includes all tables and/or figures that were used in the research study 
• Each table and figure is placed on a separate page 
• Tables are included before figures
• Begins with a bolded, centered header such as “ Table 1 ”
• Appends all forms, surveys, tests, etc. that were used in the study 
• Only includes documents that were referenced in the Methods section 
• Each entry is placed on a separate page 
• Begins with a bolded, centered header such as “ Appendix A ”

Tips For Experimental Research Papers (APA)

• Initial interest will motivate you to complete your study 
• Your entire study will be centered around this question or statement 
• Use only verifiable sources that provide accurate information about your topic 
• You need to thoroughly understand the field of study your topic is on to help you recognize the gap your research will fill and the significance of your results
• This will help you identify what you should study and what the significance of your study will be 
• Create an outline before you begin writing to help organize your thoughts and direct you in your writing 
• This will prevent you from losing the source or forgetting to cite the source 
• Work on one section at a time, rather than trying to complete multiple sections at once
• This information can be easily referred to as your write your various sections 
• When conducting your research, working general to specific will help you narrow your topic and fully understand the field your topic is in 
• When writing your literature review, writing from general to specific will help the audience understand your overall topic and the narrow focus of your research 
• This will prevent you from losing sources you may need later 
• Incorporate correct APA formatting as you write, rather than changing the formatting at the end of the writing process 

Checklist For Experimental Research Papers (APA)

• If the paper is a student paper, it contains the title of the project, the author’s name(s), the instructor's name, course number and name, and assignment due date
• If the paper is a professional paper, it includes the title of the paper, the author’s name(s), the institutional affiliation, and the author note
• Begins on the first page of the paper
• The title is typed in upper and lowercase letters, four spaces below the top of the paper, and written in boldface 
• Other information is separated by a space from the title

Title (found on title page)

• Informs the audience about the purpose of the paper 
• Captures the attention of the audience 
• Accurately reflects the purpose and content of the research paper 

Abstract 

• Labeled as “ Abstract ”
• Begins on the second page 
• Provides a short, concise summary of the content of the research paper 
• Includes background information necessary to understand the topic 
• Background information demonstrates the purpose of the paper
• Contains the hypothesis and/or research questions addressed in the paper
• Has a brief description of the methods used 
• Details the key findings and significance of the results
• Illustrates the implications of the research study 
• Contains less than 250 words

Introduction 

• Starts on the third page 
• Includes the title of the paper in bold at the top of the page
• Contains a clear statement of the problem that the paper sets out to address 
• Places the research paper within the context of previous research on the topic 
• Explains the purpose of the research study and what you hope to find
• Describes the significance of the study 
• Details what new insights the research will contribute
• Concludes with a brief description of what information will be mentioned in the literature review

Literature Review

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• Identifies any unresolved issues or gaps in research that the current research plans to address
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• Labeled as “ Methods ”
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• Appropriately divided into sections
• Describes the characteristics of the participants 
• Explains how the participants were selected 
• Details how the anonymity of the participants was protected 
• Notes what feedback the participants will be provided 
• Describes all materials and instruments that were used 
• Mentions how the procedure was conducted and data collected
• Notes the independent and dependent variables 
• Includes enough information that another researcher could duplicate the research 

Results 

• Labeled as “ Results ”
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• Omits any analysis or discussion of the implications of the study 

Discussion 

• Labeled as “ Discussion ”
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• Relates the results to the research questions and/or hypotheses
• States whether the hypotheses should be rejected or accepted 
• Addresses limitations of the study, including potential bias, confounds, imprecision of measures, and limits to generalizability
• Explains how the study adds to the knowledge base and expands upon past research
• Labeled as “ References ”
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• All sources included in the study are cited in the reference section 

Table and Figures (optional)

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• Each table and figure begins with a bolded, centered header such as “ Table 1 ,” “ Table 2 ,”

Appendix (optional) 

• Any forms, surveys, tests, etc. are placed in the Appendix
• All appendix entries are mentioned in the Methods section 
• Each appendix begins on a new page
• Each appendix begins with a bolded, centered header such as “ Appendix A, ” “ Appendix B ”

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• https://writing.wisc.edu/handbook/assignments/planresearchpaper/
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• https://www.unr.edu/writing-speaking-center/student-resources/writing-speaking-resources/guide-to-writing-research-papers
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• https://owl.purdue.edu/owl/research_and_citation/apa_style/apa_formatting_and_style_guide/general_format.html
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• A Quick Guide to Experimental Design | 5 Steps & Examples

A Quick Guide to Experimental Design | 5 Steps & Examples

Published on 11 April 2022 by Rebecca Bevans . Revised on 5 December 2022.

Experiments are used to study causal relationships . You manipulate one or more independent variables and measure their effect on one or more dependent variables.

Experimental design means creating a set of procedures to systematically test a hypothesis . A good experimental design requires a strong understanding of the system you are studying. 

There are five key steps in designing an experiment:

• Consider your variables and how they are related
• Write a specific, testable hypothesis
• Design experimental treatments to manipulate your independent variable
• Assign subjects to groups, either between-subjects or within-subjects
• Plan how you will measure your dependent variable

For valid conclusions, you also need to select a representative sample and control any  extraneous variables that might influence your results. If if random assignment of participants to control and treatment groups is impossible, unethical, or highly difficult, consider an observational study instead.

Table of contents

Step 1: define your variables, step 2: write your hypothesis, step 3: design your experimental treatments, step 4: assign your subjects to treatment groups, step 5: measure your dependent variable, frequently asked questions about experimental design.

You should begin with a specific research question . We will work with two research question examples, one from health sciences and one from ecology:

To translate your research question into an experimental hypothesis, you need to define the main variables and make predictions about how they are related.

Start by simply listing the independent and dependent variables .

Then you need to think about possible extraneous and confounding variables and consider how you might control  them in your experiment.

Finally, you can put these variables together into a diagram. Use arrows to show the possible relationships between variables and include signs to show the expected direction of the relationships.

Here we predict that increasing temperature will increase soil respiration and decrease soil moisture, while decreasing soil moisture will lead to decreased soil respiration.

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Now that you have a strong conceptual understanding of the system you are studying, you should be able to write a specific, testable hypothesis that addresses your research question.

The next steps will describe how to design a controlled experiment . In a controlled experiment, you must be able to:

• Systematically and precisely manipulate the independent variable(s).
• Precisely measure the dependent variable(s).
• Control any potential confounding variables.

If your study system doesn’t match these criteria, there are other types of research you can use to answer your research question.

How you manipulate the independent variable can affect the experiment’s external validity – that is, the extent to which the results can be generalised and applied to the broader world.

First, you may need to decide how widely to vary your independent variable.

• just slightly above the natural range for your study region.
• over a wider range of temperatures to mimic future warming.
• over an extreme range that is beyond any possible natural variation.

Second, you may need to choose how finely to vary your independent variable. Sometimes this choice is made for you by your experimental system, but often you will need to decide, and this will affect how much you can infer from your results.

• a categorical variable : either as binary (yes/no) or as levels of a factor (no phone use, low phone use, high phone use).
• a continuous variable (minutes of phone use measured every night).

How you apply your experimental treatments to your test subjects is crucial for obtaining valid and reliable results.

First, you need to consider the study size : how many individuals will be included in the experiment? In general, the more subjects you include, the greater your experiment’s statistical power , which determines how much confidence you can have in your results.

Then you need to randomly assign your subjects to treatment groups . Each group receives a different level of the treatment (e.g. no phone use, low phone use, high phone use).

You should also include a control group , which receives no treatment. The control group tells us what would have happened to your test subjects without any experimental intervention.

When assigning your subjects to groups, there are two main choices you need to make:

• A completely randomised design vs a randomised block design .
• A between-subjects design vs a within-subjects design .

Randomisation

An experiment can be completely randomised or randomised within blocks (aka strata):

• In a completely randomised design , every subject is assigned to a treatment group at random.
• In a randomised block design (aka stratified random design), subjects are first grouped according to a characteristic they share, and then randomly assigned to treatments within those groups.

Sometimes randomisation isn’t practical or ethical , so researchers create partially-random or even non-random designs. An experimental design where treatments aren’t randomly assigned is called a quasi-experimental design .

Between-subjects vs within-subjects

In a between-subjects design (also known as an independent measures design or classic ANOVA design), individuals receive only one of the possible levels of an experimental treatment.

In medical or social research, you might also use matched pairs within your between-subjects design to make sure that each treatment group contains the same variety of test subjects in the same proportions.

In a within-subjects design (also known as a repeated measures design), every individual receives each of the experimental treatments consecutively, and their responses to each treatment are measured.

Within-subjects or repeated measures can also refer to an experimental design where an effect emerges over time, and individual responses are measured over time in order to measure this effect as it emerges.

Counterbalancing (randomising or reversing the order of treatments among subjects) is often used in within-subjects designs to ensure that the order of treatment application doesn’t influence the results of the experiment.

Finally, you need to decide how you’ll collect data on your dependent variable outcomes. You should aim for reliable and valid measurements that minimise bias or error.

Some variables, like temperature, can be objectively measured with scientific instruments. Others may need to be operationalised to turn them into measurable observations.

• Ask participants to record what time they go to sleep and get up each day.
• Ask participants to wear a sleep tracker.

How precisely you measure your dependent variable also affects the kinds of statistical analysis you can use on your data.

Experiments are always context-dependent, and a good experimental design will take into account all of the unique considerations of your study system to produce information that is both valid and relevant to your research question.

Experimental designs are a set of procedures that you plan in order to examine the relationship between variables that interest you.

To design a successful experiment, first identify:

• A testable hypothesis
• One or more independent variables that you will manipulate
• One or more dependent variables that you will measure

When designing the experiment, first decide:

• How your variable(s) will be manipulated
• How you will control for any potential confounding or lurking variables
• How many subjects you will include
• How you will assign treatments to your subjects

The key difference between observational studies and experiments is that, done correctly, an observational study will never influence the responses or behaviours of participants. Experimental designs will have a treatment condition applied to at least a portion of participants.

A confounding variable , also called a confounder or confounding factor, is a third variable in a study examining a potential cause-and-effect relationship.

A confounding variable is related to both the supposed cause and the supposed effect of the study. It can be difficult to separate the true effect of the independent variable from the effect of the confounding variable.

In your research design , it’s important to identify potential confounding variables and plan how you will reduce their impact.

In a between-subjects design , every participant experiences only one condition, and researchers assess group differences between participants in various conditions.

In a within-subjects design , each participant experiences all conditions, and researchers test the same participants repeatedly for differences between conditions.

The word ‘between’ means that you’re comparing different conditions between groups, while the word ‘within’ means you’re comparing different conditions within the same group.

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Rebecca Bevans

Experimental design: Guide, steps, examples

Last updated

27 April 2023

Reviewed by

Miroslav Damyanov

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Experimental research design is a scientific framework that allows you to manipulate one or more variables while controlling the test environment. 

When testing a theory or new product, it can be helpful to have a certain level of control and manipulate variables to discover different outcomes. You can use these experiments to determine cause and effect or study variable associations. 

This guide explores the types of experimental design, the steps in designing an experiment, and the advantages and limitations of experimental design. 

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• What is experimental research design?

You can determine the relationship between each of the variables by: 

Manipulating one or more independent variables (i.e., stimuli or treatments)

Applying the changes to one or more dependent variables (i.e., test groups or outcomes)

With the ability to analyze the relationship between variables and using measurable data, you can increase the accuracy of the result. 

What is a good experimental design?

A good experimental design requires: 

Significant planning to ensure control over the testing environment

Sound experimental treatments

Properly assigning subjects to treatment groups

Without proper planning, unexpected external variables can alter an experiment's outcome. 

To meet your research goals, your experimental design should include these characteristics:

Provide unbiased estimates of inputs and associated uncertainties

Enable the researcher to detect differences caused by independent variables

Include a plan for analysis and reporting of the results

Provide easily interpretable results with specific conclusions

What's the difference between experimental and quasi-experimental design?

The major difference between experimental and quasi-experimental design is the random assignment of subjects to groups. 

A true experiment relies on certain controls. Typically, the researcher designs the treatment and randomly assigns subjects to control and treatment groups. 

However, these conditions are unethical or impossible to achieve in some situations.

When it's unethical or impractical to assign participants randomly, that’s when a quasi-experimental design comes in. 

This design allows researchers to conduct a similar experiment by assigning subjects to groups based on non-random criteria. 

Another type of quasi-experimental design might occur when the researcher doesn't have control over the treatment but studies pre-existing groups after they receive different treatments.

When can a researcher conduct experimental research?

Various settings and professions can use experimental research to gather information and observe behavior in controlled settings. 

Basically, a researcher can conduct experimental research any time they want to test a theory with variable and dependent controls. 

Experimental research is an option when the project includes an independent variable and a desire to understand the relationship between cause and effect. 

• The importance of experimental research design

Experimental research enables researchers to conduct studies that provide specific, definitive answers to questions and hypotheses. 

Researchers can test Independent variables in controlled settings to:

Test the effectiveness of a new medication

Design better products for consumers

Answer questions about human health and behavior

Developing a quality research plan means a researcher can accurately answer vital research questions with minimal error. As a result, definitive conclusions can influence the future of the independent variable. 

Types of experimental research designs

There are three main types of experimental research design. The research type you use will depend on the criteria of your experiment, your research budget, and environmental limitations. 

Pre-experimental research design

A pre-experimental research study is a basic observational study that monitors independent variables’ effects. 

During research, you observe one or more groups after applying a treatment to test whether the treatment causes any change. 

The three subtypes of pre-experimental research design are:

One-shot case study research design

This research method introduces a single test group to a single stimulus to study the results at the end of the application. 

After researchers presume the stimulus or treatment has caused changes, they gather results to determine how it affects the test subjects. 

One-group pretest-posttest design

This method uses a single test group but includes a pretest study as a benchmark. The researcher applies a test before and after the group’s exposure to a specific stimulus. 

Static group comparison design

This method includes two or more groups, enabling the researcher to use one group as a control. They apply a stimulus to one group and leave the other group static. 

A posttest study compares the results among groups. 

True experimental research design

A true experiment is the most common research method. It involves statistical analysis to prove or disprove a specific hypothesis . 

Under completely experimental conditions, researchers expose participants in two or more randomized groups to different stimuli. 

Random selection removes any potential for bias, providing more reliable results. 

These are the three main sub-groups of true experimental research design:

Posttest-only control group design

This structure requires the researcher to divide participants into two random groups. One group receives no stimuli and acts as a control while the other group experiences stimuli.

Researchers perform a test at the end of the experiment to observe the stimuli exposure results.

Pretest-posttest control group design

This test also requires two groups. It includes a pretest as a benchmark before introducing the stimulus. 

The pretest introduces multiple ways to test subjects. For instance, if the control group also experiences a change, it reveals that taking the test twice changes the results.

Solomon four-group design

This structure divides subjects into two groups, with two as control groups. Researchers assign the first control group a posttest only and the second control group a pretest and a posttest. 

The two variable groups mirror the control groups, but researchers expose them to stimuli. The ability to differentiate between groups in multiple ways provides researchers with more testing approaches for data-based conclusions. 

Quasi-experimental research design

Although closely related to a true experiment, quasi-experimental research design differs in approach and scope. 

Quasi-experimental research design doesn’t have randomly selected participants. Researchers typically divide the groups in this research by pre-existing differences. 

Quasi-experimental research is more common in educational studies, nursing, or other research projects where it's not ethical or practical to use randomized subject groups.

• 5 steps for designing an experiment

Experimental research requires a clearly defined plan to outline the research parameters and expected goals. 

Here are five key steps in designing a successful experiment:

Step 1: Define variables and their relationship

Your experiment should begin with a question: What are you hoping to learn through your experiment? 

The relationship between variables in your study will determine your answer.

Define the independent variable (the intended stimuli) and the dependent variable (the expected effect of the stimuli). After identifying these groups, consider how you might control them in your experiment. 

Could natural variations affect your research? If so, your experiment should include a pretest and posttest. 

Step 2: Develop a specific, testable hypothesis

With a firm understanding of the system you intend to study, you can write a specific, testable hypothesis. 

What is the expected outcome of your study? 

Develop a prediction about how the independent variable will affect the dependent variable. 

How will the stimuli in your experiment affect your test subjects? 

Your hypothesis should provide a prediction of the answer to your research question . 

Step 3: Design experimental treatments to manipulate your independent variable

Depending on your experiment, your variable may be a fixed stimulus (like a medical treatment) or a variable stimulus (like a period during which an activity occurs). 

Determine which type of stimulus meets your experiment’s needs and how widely or finely to vary your stimuli. 

Step 4: Assign subjects to groups

When you have a clear idea of how to carry out your experiment, you can determine how to assemble test groups for an accurate study. 

When choosing your study groups, consider: 

The size of your experiment

Whether you can select groups randomly

Your target audience for the outcome of the study

You should be able to create groups with an equal number of subjects and include subjects that match your target audience. Remember, you should assign one group as a control and use one or more groups to study the effects of variables. 

Step 5: Plan how to measure your dependent variable

This step determines how you'll collect data to determine the study's outcome. You should seek reliable and valid measurements that minimize research bias or error. 

You can measure some data with scientific tools, while you’ll need to operationalize other forms to turn them into measurable observations.

• Advantages of experimental research

Experimental research is an integral part of our world. It allows researchers to conduct experiments that answer specific questions. 

While researchers use many methods to conduct different experiments, experimental research offers these distinct benefits:

Researchers can determine cause and effect by manipulating variables.

It gives researchers a high level of control.

Researchers can test multiple variables within a single experiment.

All industries and fields of knowledge can use it. 

Researchers can duplicate results to promote the validity of the study .

Replicating natural settings rapidly means immediate research.

Researchers can combine it with other research methods.

It provides specific conclusions about the validity of a product, theory, or idea.

• Disadvantages (or limitations) of experimental research

Unfortunately, no research type yields ideal conditions or perfect results. 

While experimental research might be the right choice for some studies, certain conditions could render experiments useless or even dangerous. 

Before conducting experimental research, consider these disadvantages and limitations:

Required professional qualification

Only competent professionals with an academic degree and specific training are qualified to conduct rigorous experimental research. This ensures results are unbiased and valid. 

Limited scope

Experimental research may not capture the complexity of some phenomena, such as social interactions or cultural norms. These are difficult to control in a laboratory setting.

Resource-intensive

Experimental research can be expensive, time-consuming, and require significant resources, such as specialized equipment or trained personnel.

Limited generalizability

The controlled nature means the research findings may not fully apply to real-world situations or people outside the experimental setting.

Practical or ethical concerns

Some experiments may involve manipulating variables that could harm participants or violate ethical guidelines . 

Researchers must ensure their experiments do not cause harm or discomfort to participants. 

Sometimes, recruiting a sample of people to randomly assign may be difficult. 

• Experimental research design example

Experiments across all industries and research realms provide scientists, developers, and other researchers with definitive answers. These experiments can solve problems, create inventions, and heal illnesses. 

Product design testing is an excellent example of experimental research. 

A company in the product development phase creates multiple prototypes for testing. With a randomized selection, researchers introduce each test group to a different prototype. 

When groups experience different product designs , the company can assess which option most appeals to potential customers. 

Experimental research design provides researchers with a controlled environment to conduct experiments that evaluate cause and effect. 

Using the five steps to develop a research plan ensures you anticipate and eliminate external variables while answering life’s crucial questions.

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Chapter 10 Experimental Research

Experimental research, often considered to be the “gold standard” in research designs, is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different treatment levels (random assignment), and the results of the treatments on outcomes (dependent variables) are observed. The unique strength of experimental research is its internal validity (causality) due to its ability to link cause and effect through treatment manipulation, while controlling for the spurious effect of extraneous variable.

Experimental research is best suited for explanatory research (rather than for descriptive or exploratory research), where the goal of the study is to examine cause-effect relationships. It also works well for research that involves a relatively limited and well-defined set of independent variables that can either be manipulated or controlled. Experimental research can be conducted in laboratory or field settings. Laboratory experiments , conducted in laboratory (artificial) settings, tend to be high in internal validity, but this comes at the cost of low external validity (generalizability), because the artificial (laboratory) setting in which the study is conducted may not reflect the real world. Field experiments , conducted in field settings such as in a real organization, and high in both internal and external validity. But such experiments are relatively rare, because of the difficulties associated with manipulating treatments and controlling for extraneous effects in a field setting.

Experimental research can be grouped into two broad categories: true experimental designs and quasi-experimental designs. Both designs require treatment manipulation, but while true experiments also require random assignment, quasi-experiments do not. Sometimes, we also refer to non-experimental research, which is not really a research design, but an all-inclusive term that includes all types of research that do not employ treatment manipulation or random assignment, such as survey research, observational research, and correlational studies.

Basic Concepts

Treatment and control groups. In experimental research, some subjects are administered one or more experimental stimulus called a treatment (the treatment group ) while other subjects are not given such a stimulus (the control group ). The treatment may be considered successful if subjects in the treatment group rate more favorably on outcome variables than control group subjects. Multiple levels of experimental stimulus may be administered, in which case, there may be more than one treatment group. For example, in order to test the effects of a new drug intended to treat a certain medical condition like dementia, if a sample of dementia patients is randomly divided into three groups, with the first group receiving a high dosage of the drug, the second group receiving a low dosage, and the third group receives a placebo such as a sugar pill (control group), then the first two groups are experimental groups and the third group is a control group. After administering the drug for a period of time, if the condition of the experimental group subjects improved significantly more than the control group subjects, we can say that the drug is effective. We can also compare the conditions of the high and low dosage experimental groups to determine if the high dose is more effective than the low dose.

Treatment manipulation. Treatments are the unique feature of experimental research that sets this design apart from all other research methods. Treatment manipulation helps control for the “cause” in cause-effect relationships. Naturally, the validity of experimental research depends on how well the treatment was manipulated. Treatment manipulation must be checked using pretests and pilot tests prior to the experimental study. Any measurements conducted before the treatment is administered are called pretest measures , while those conducted after the treatment are posttest measures .

Random selection and assignment. Random selection is the process of randomly drawing a sample from a population or a sampling frame. This approach is typically employed in survey research, and assures that each unit in the population has a positive chance of being selected into the sample. Random assignment is however a process of randomly assigning subjects to experimental or control groups. This is a standard practice in true experimental research to ensure that treatment groups are similar (equivalent) to each other and to the control group, prior to treatment administration. Random selection is related to sampling, and is therefore, more closely related to the external validity (generalizability) of findings. However, random assignment is related to design, and is therefore most related to internal validity. It is possible to have both random selection and random assignment in well-designed experimental research, but quasi-experimental research involves neither random selection nor random assignment.

Threats to internal validity. Although experimental designs are considered more rigorous than other research methods in terms of the internal validity of their inferences (by virtue of their ability to control causes through treatment manipulation), they are not immune to internal validity threats. Some of these threats to internal validity are described below, within the context of a study of the impact of a special remedial math tutoring program for improving the math abilities of high school students.

• History threat is the possibility that the observed effects (dependent variables) are caused by extraneous or historical events rather than by the experimental treatment. For instance, students’ post-remedial math score improvement may have been caused by their preparation for a math exam at their school, rather than the remedial math program.
• Maturation threat refers to the possibility that observed effects are caused by natural maturation of subjects (e.g., a general improvement in their intellectual ability to understand complex concepts) rather than the experimental treatment.
• Testing threat is a threat in pre-post designs where subjects’ posttest responses are conditioned by their pretest responses. For instance, if students remember their answers from the pretest evaluation, they may tend to repeat them in the posttest exam. Not conducting a pretest can help avoid this threat.
• Instrumentation threat , which also occurs in pre-post designs, refers to the possibility that the difference between pretest and posttest scores is not due to the remedial math program, but due to changes in the administered test, such as the posttest having a higher or lower degree of difficulty than the pretest.
• Mortality threat refers to the possibility that subjects may be dropping out of the study at differential rates between the treatment and control groups due to a systematic reason, such that the dropouts were mostly students who scored low on the pretest. If the low-performing students drop out, the results of the posttest will be artificially inflated by the preponderance of high-performing students.
• Regression threat , also called a regression to the mean, refers to the statistical tendency of a group’s overall performance on a measure during a posttest to regress toward the mean of that measure rather than in the anticipated direction. For instance, if subjects scored high on a pretest, they will have a tendency to score lower on the posttest (closer to the mean) because their high scores (away from the mean) during the pretest was possibly a statistical aberration. This problem tends to be more prevalent in non-random samples and when the two measures are imperfectly correlated.

Two-Group Experimental Designs

The simplest true experimental designs are two group designs involving one treatment group and one control group, and are ideally suited for testing the effects of a single independent variable that can be manipulated as a treatment. The two basic two-group designs are the pretest-posttest control group design and the posttest-only control group design, while variations may include covariance designs. These designs are often depicted using a standardized design notation, where R represents random assignment of subjects to groups, X represents the treatment administered to the treatment group, and O represents pretest or posttest observations of the dependent variable (with different subscripts to distinguish between pretest and posttest observations of treatment and control groups).

Pretest-posttest control group design . In this design, subjects are randomly assigned to treatment and control groups, subjected to an initial (pretest) measurement of the dependent variables of interest, the treatment group is administered a treatment (representing the independent variable of interest), and the dependent variables measured again (posttest). The notation of this design is shown in Figure 10.1.

Figure 10.1. Pretest-posttest control group design

The effect E of the experimental treatment in the pretest posttest design is measured as the difference in the posttest and pretest scores between the treatment and control groups:

E = (O 2 – O 1 ) – (O 4 – O 3 )

Statistical analysis of this design involves a simple analysis of variance (ANOVA) between the treatment and control groups. The pretest posttest design handles several threats to internal validity, such as maturation, testing, and regression, since these threats can be expected to influence both treatment and control groups in a similar (random) manner. The selection threat is controlled via random assignment. However, additional threats to internal validity may exist. For instance, mortality can be a problem if there are differential dropout rates between the two groups, and the pretest measurement may bias the posttest measurement (especially if the pretest introduces unusual topics or content).

Posttest-only control group design . This design is a simpler version of the pretest-posttest design where pretest measurements are omitted. The design notation is shown in Figure 10.2.

Figure 10.2. Posttest only control group design.

The treatment effect is measured simply as the difference in the posttest scores between the two groups:

E = (O 1 – O 2 )

The appropriate statistical analysis of this design is also a two- group analysis of variance (ANOVA). The simplicity of this design makes it more attractive than the pretest-posttest design in terms of internal validity. This design controls for maturation, testing, regression, selection, and pretest-posttest interaction, though the mortality threat may continue to exist.

Covariance designs . Sometimes, measures of dependent variables may be influenced by extraneous variables called covariates . Covariates are those variables that are not of central interest to an experimental study, but should nevertheless be controlled in an experimental design in order to eliminate their potential effect on the dependent variable and therefore allow for a more accurate detection of the effects of the independent variables of interest. The experimental designs discussed earlier did not control for such covariates. A covariance design (also called a concomitant variable design) is a special type of pretest posttest control group design where the pretest measure is essentially a measurement of the covariates of interest rather than that of the dependent variables. The design notation is shown in Figure 10.3, where C represents the covariates:

Figure 10.3. Covariance design

Because the pretest measure is not a measurement of the dependent variable, but rather a covariate, the treatment effect is measured as the difference in the posttest scores between the treatment and control groups as:

Figure 10.4. 2 x 2 factorial design

Factorial designs can also be depicted using a design notation, such as that shown on the right panel of Figure 10.4. R represents random assignment of subjects to treatment groups, X represents the treatment groups themselves (the subscripts of X represents the level of each factor), and O represent observations of the dependent variable. Notice that the 2 x 2 factorial design will have four treatment groups, corresponding to the four combinations of the two levels of each factor. Correspondingly, the 2 x 3 design will have six treatment groups, and the 2 x 2 x 2 design will have eight treatment groups. As a rule of thumb, each cell in a factorial design should have a minimum sample size of 20 (this estimate is derived from Cohen’s power calculations based on medium effect sizes). So a 2 x 2 x 2 factorial design requires a minimum total sample size of 160 subjects, with at least 20 subjects in each cell. As you can see, the cost of data collection can increase substantially with more levels or factors in your factorial design. Sometimes, due to resource constraints, some cells in such factorial designs may not receive any treatment at all, which are called incomplete factorial designs . Such incomplete designs hurt our ability to draw inferences about the incomplete factors.

In a factorial design, a main effect is said to exist if the dependent variable shows a significant difference between multiple levels of one factor, at all levels of other factors. No change in the dependent variable across factor levels is the null case (baseline), from which main effects are evaluated. In the above example, you may see a main effect of instructional type, instructional time, or both on learning outcomes. An interaction effect exists when the effect of differences in one factor depends upon the level of a second factor. In our example, if the effect of instructional type on learning outcomes is greater for 3 hours/week of instructional time than for 1.5 hours/week, then we can say that there is an interaction effect between instructional type and instructional time on learning outcomes. Note that the presence of interaction effects dominate and make main effects irrelevant, and it is not meaningful to interpret main effects if interaction effects are significant.

Hybrid Experimental Designs

Hybrid designs are those that are formed by combining features of more established designs. Three such hybrid designs are randomized bocks design, Solomon four-group design, and switched replications design.

Randomized block design. This is a variation of the posttest-only or pretest-posttest control group design where the subject population can be grouped into relatively homogeneous subgroups (called blocks ) within which the experiment is replicated. For instance, if you want to replicate the same posttest-only design among university students and full -time working professionals (two homogeneous blocks), subjects in both blocks are randomly split between treatment group (receiving the same treatment) or control group (see Figure 10.5). The purpose of this design is to reduce the “noise” or variance in data that may be attributable to differences between the blocks so that the actual effect of interest can be detected more accurately.

Figure 10.5. Randomized blocks design.

Solomon four-group design . In this design, the sample is divided into two treatment groups and two control groups. One treatment group and one control group receive the pretest, and the other two groups do not. This design represents a combination of posttest-only and pretest-posttest control group design, and is intended to test for the potential biasing effect of pretest measurement on posttest measures that tends to occur in pretest-posttest designs but not in posttest only designs. The design notation is shown in Figure 10.6.

Figure 10.6. Solomon four-group design

Switched replication design . This is a two-group design implemented in two phases with three waves of measurement. The treatment group in the first phase serves as the control group in the second phase, and the control group in the first phase becomes the treatment group in the second phase, as illustrated in Figure 10.7. In other words, the original design is repeated or replicated temporally with treatment/control roles switched between the two groups. By the end of the study, all participants will have received the treatment either during the first or the second phase. This design is most feasible in organizational contexts where organizational programs (e.g., employee training) are implemented in a phased manner or are repeated at regular intervals.

Figure 10.7. Switched replication design.

Quasi-Experimental Designs

Quasi-experimental designs are almost identical to true experimental designs, but lacking one key ingredient: random assignment. For instance, one entire class section or one organization is used as the treatment group, while another section of the same class or a different organization in the same industry is used as the control group. This lack of random assignment potentially results in groups that are non-equivalent, such as one group possessing greater mastery of a certain content than the other group, say by virtue of having a better teacher in a previous semester, which introduces the possibility of selection bias . Quasi-experimental designs are therefore inferior to true experimental designs in interval validity due to the presence of a variety of selection related threats such as selection-maturation threat (the treatment and control groups maturing at different rates), selection-history threat (the treatment and control groups being differentially impact by extraneous or historical events), selection-regression threat (the treatment and control groups regressing toward the mean between pretest and posttest at different rates), selection-instrumentation threat (the treatment and control groups responding differently to the measurement), selection-testing (the treatment and control groups responding differently to the pretest), and selection-mortality (the treatment and control groups demonstrating differential dropout rates). Given these selection threats, it is generally preferable to avoid quasi-experimental designs to the greatest extent possible.

Many true experimental designs can be converted to quasi-experimental designs by omitting random assignment. For instance, the quasi-equivalent version of pretest-posttest control group design is called nonequivalent groups design (NEGD), as shown in Figure 10.8, with random assignment R replaced by non-equivalent (non-random) assignment N . Likewise, the quasi -experimental version of switched replication design is called non-equivalent switched replication design (see Figure 10.9).

Figure 10.8. NEGD design.

Figure 10.9. Non-equivalent switched replication design.

In addition, there are quite a few unique non -equivalent designs without corresponding true experimental design cousins. Some of the more useful of these designs are discussed next.

Regression-discontinuity (RD) design . This is a non-equivalent pretest-posttest design where subjects are assigned to treatment or control group based on a cutoff score on a preprogram measure. For instance, patients who are severely ill may be assigned to a treatment group to test the efficacy of a new drug or treatment protocol and those who are mildly ill are assigned to the control group. In another example, students who are lagging behind on standardized test scores may be selected for a remedial curriculum program intended to improve their performance, while those who score high on such tests are not selected from the remedial program. The design notation can be represented as follows, where C represents the cutoff score:

Figure 10.10. RD design.

Because of the use of a cutoff score, it is possible that the observed results may be a function of the cutoff score rather than the treatment, which introduces a new threat to internal validity. However, using the cutoff score also ensures that limited or costly resources are distributed to people who need them the most rather than randomly across a population, while simultaneously allowing a quasi-experimental treatment. The control group scores in the RD design does not serve as a benchmark for comparing treatment group scores, given the systematic non-equivalence between the two groups. Rather, if there is no discontinuity between pretest and posttest scores in the control group, but such a discontinuity persists in the treatment group, then this discontinuity is viewed as evidence of the treatment effect.

Proxy pretest design . This design, shown in Figure 10.11, looks very similar to the standard NEGD (pretest-posttest) design, with one critical difference: the pretest score is collected after the treatment is administered. A typical application of this design is when a researcher is brought in to test the efficacy of a program (e.g., an educational program) after the program has already started and pretest data is not available. Under such circumstances, the best option for the researcher is often to use a different prerecorded measure, such as students’ grade point average before the start of the program, as a proxy for pretest data. A variation of the proxy pretest design is to use subjects’ posttest recollection of pretest data, which may be subject to recall bias, but nevertheless may provide a measure of perceived gain or change in the dependent variable.

Figure 10.11. Proxy pretest design.

Separate pretest-posttest samples design . This design is useful if it is not possible to collect pretest and posttest data from the same subjects for some reason. As shown in Figure 10.12, there are four groups in this design, but two groups come from a single non-equivalent group, while the other two groups come from a different non-equivalent group. For instance, you want to test customer satisfaction with a new online service that is implemented in one city but not in another. In this case, customers in the first city serve as the treatment group and those in the second city constitute the control group. If it is not possible to obtain pretest and posttest measures from the same customers, you can measure customer satisfaction at one point in time, implement the new service program, and measure customer satisfaction (with a different set of customers) after the program is implemented. Customer satisfaction is also measured in the control group at the same times as in the treatment group, but without the new program implementation. The design is not particularly strong, because you cannot examine the changes in any specific customer’s satisfaction score before and after the implementation, but you can only examine average customer satisfaction scores. Despite the lower internal validity, this design may still be a useful way of collecting quasi-experimental data when pretest and posttest data are not available from the same subjects.

Figure 10.12. Separate pretest-posttest samples design.

Nonequivalent dependent variable (NEDV) design . This is a single-group pre-post quasi-experimental design with two outcome measures, where one measure is theoretically expected to be influenced by the treatment and the other measure is not. For instance, if you are designing a new calculus curriculum for high school students, this curriculum is likely to influence students’ posttest calculus scores but not algebra scores. However, the posttest algebra scores may still vary due to extraneous factors such as history or maturation. Hence, the pre-post algebra scores can be used as a control measure, while that of pre-post calculus can be treated as the treatment measure. The design notation, shown in Figure 10.13, indicates the single group by a single N , followed by pretest O 1 and posttest O 2 for calculus and algebra for the same group of students. This design is weak in internal validity, but its advantage lies in not having to use a separate control group.

An interesting variation of the NEDV design is a pattern matching NEDV design , which employs multiple outcome variables and a theory that explains how much each variable will be affected by the treatment. The researcher can then examine if the theoretical prediction is matched in actual observations. This pattern-matching technique, based on the degree of correspondence between theoretical and observed patterns is a powerful way of alleviating internal validity concerns in the original NEDV design.

Figure 10.13. NEDV design.

Perils of Experimental Research

Experimental research is one of the most difficult of research designs, and should not be taken lightly. This type of research is often best with a multitude of methodological problems. First, though experimental research requires theories for framing hypotheses for testing, much of current experimental research is atheoretical. Without theories, the hypotheses being tested tend to be ad hoc, possibly illogical, and meaningless. Second, many of the measurement instruments used in experimental research are not tested for reliability and validity, and are incomparable across studies. Consequently, results generated using such instruments are also incomparable. Third, many experimental research use inappropriate research designs, such as irrelevant dependent variables, no interaction effects, no experimental controls, and non-equivalent stimulus across treatment groups. Findings from such studies tend to lack internal validity and are highly suspect. Fourth, the treatments (tasks) used in experimental research may be diverse, incomparable, and inconsistent across studies and sometimes inappropriate for the subject population. For instance, undergraduate student subjects are often asked to pretend that they are marketing managers and asked to perform a complex budget allocation task in which they have no experience or expertise. The use of such inappropriate tasks, introduces new threats to internal validity (i.e., subject’s performance may be an artifact of the content or difficulty of the task setting), generates findings that are non-interpretable and meaningless, and makes integration of findings across studies impossible.

The design of proper experimental treatments is a very important task in experimental design, because the treatment is the raison d’etre of the experimental method, and must never be rushed or neglected. To design an adequate and appropriate task, researchers should use prevalidated tasks if available, conduct treatment manipulation checks to check for the adequacy of such tasks (by debriefing subjects after performing the assigned task), conduct pilot tests (repeatedly, if necessary), and if doubt, using tasks that are simpler and familiar for the respondent sample than tasks that are complex or unfamiliar.

In summary, this chapter introduced key concepts in the experimental design research method and introduced a variety of true experimental and quasi-experimental designs. Although these designs vary widely in internal validity, designs with less internal validity should not be overlooked and may sometimes be useful under specific circumstances and empirical contingencies.

• Social Science Research: Principles, Methods, and Practices. Authored by : Anol Bhattacherjee. Provided by : University of South Florida. Located at : http://scholarcommons.usf.edu/oa_textbooks/3/ . License : CC BY-NC-SA: Attribution-NonCommercial-ShareAlike

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Experimental Design – Types, Methods, Guide

Table of Contents

Experimental Design

Experimental design is a process of planning and conducting scientific experiments to investigate a hypothesis or research question. It involves carefully designing an experiment that can test the hypothesis, and controlling for other variables that may influence the results.

Experimental design typically includes identifying the variables that will be manipulated or measured, defining the sample or population to be studied, selecting an appropriate method of sampling, choosing a method for data collection and analysis, and determining the appropriate statistical tests to use.

Types of Experimental Design

Here are the different types of experimental design:

Completely Randomized Design

In this design, participants are randomly assigned to one of two or more groups, and each group is exposed to a different treatment or condition.

Randomized Block Design

This design involves dividing participants into blocks based on a specific characteristic, such as age or gender, and then randomly assigning participants within each block to one of two or more treatment groups.

Factorial Design

In a factorial design, participants are randomly assigned to one of several groups, each of which receives a different combination of two or more independent variables.

Repeated Measures Design

In this design, each participant is exposed to all of the different treatments or conditions, either in a random order or in a predetermined order.

Crossover Design

This design involves randomly assigning participants to one of two or more treatment groups, with each group receiving one treatment during the first phase of the study and then switching to a different treatment during the second phase.

Split-plot Design

In this design, the researcher manipulates one or more variables at different levels and uses a randomized block design to control for other variables.

Nested Design

This design involves grouping participants within larger units, such as schools or households, and then randomly assigning these units to different treatment groups.

Laboratory Experiment

Laboratory experiments are conducted under controlled conditions, which allows for greater precision and accuracy. However, because laboratory conditions are not always representative of real-world conditions, the results of these experiments may not be generalizable to the population at large.

Field Experiment

Field experiments are conducted in naturalistic settings and allow for more realistic observations. However, because field experiments are not as controlled as laboratory experiments, they may be subject to more sources of error.

Experimental Design Methods

Experimental design methods refer to the techniques and procedures used to design and conduct experiments in scientific research. Here are some common experimental design methods:

Randomization

This involves randomly assigning participants to different groups or treatments to ensure that any observed differences between groups are due to the treatment and not to other factors.

Control Group

The use of a control group is an important experimental design method that involves having a group of participants that do not receive the treatment or intervention being studied. The control group is used as a baseline to compare the effects of the treatment group.

Blinding involves keeping participants, researchers, or both unaware of which treatment group participants are in, in order to reduce the risk of bias in the results.

Counterbalancing

This involves systematically varying the order in which participants receive treatments or interventions in order to control for order effects.

Replication

Replication involves conducting the same experiment with different samples or under different conditions to increase the reliability and validity of the results.

This experimental design method involves manipulating multiple independent variables simultaneously to investigate their combined effects on the dependent variable.

This involves dividing participants into subgroups or blocks based on specific characteristics, such as age or gender, in order to reduce the risk of confounding variables.

Data Collection Method

Experimental design data collection methods are techniques and procedures used to collect data in experimental research. Here are some common experimental design data collection methods:

Direct Observation

This method involves observing and recording the behavior or phenomenon of interest in real time. It may involve the use of structured or unstructured observation, and may be conducted in a laboratory or naturalistic setting.

Self-report Measures

Self-report measures involve asking participants to report their thoughts, feelings, or behaviors using questionnaires, surveys, or interviews. These measures may be administered in person or online.

Behavioral Measures

Behavioral measures involve measuring participants’ behavior directly, such as through reaction time tasks or performance tests. These measures may be administered using specialized equipment or software.

Physiological Measures

Physiological measures involve measuring participants’ physiological responses, such as heart rate, blood pressure, or brain activity, using specialized equipment. These measures may be invasive or non-invasive, and may be administered in a laboratory or clinical setting.

Archival Data

Archival data involves using existing records or data, such as medical records, administrative records, or historical documents, as a source of information. These data may be collected from public or private sources.

Computerized Measures

Computerized measures involve using software or computer programs to collect data on participants’ behavior or responses. These measures may include reaction time tasks, cognitive tests, or other types of computer-based assessments.

Video Recording

Video recording involves recording participants’ behavior or interactions using cameras or other recording equipment. This method can be used to capture detailed information about participants’ behavior or to analyze social interactions.

Data Analysis Method

Experimental design data analysis methods refer to the statistical techniques and procedures used to analyze data collected in experimental research. Here are some common experimental design data analysis methods:

Descriptive Statistics

Descriptive statistics are used to summarize and describe the data collected in the study. This includes measures such as mean, median, mode, range, and standard deviation.

Inferential Statistics

Inferential statistics are used to make inferences or generalizations about a larger population based on the data collected in the study. This includes hypothesis testing and estimation.

Analysis of Variance (ANOVA)

ANOVA is a statistical technique used to compare means across two or more groups in order to determine whether there are significant differences between the groups. There are several types of ANOVA, including one-way ANOVA, two-way ANOVA, and repeated measures ANOVA.

Regression Analysis

Regression analysis is used to model the relationship between two or more variables in order to determine the strength and direction of the relationship. There are several types of regression analysis, including linear regression, logistic regression, and multiple regression.

Factor Analysis

Factor analysis is used to identify underlying factors or dimensions in a set of variables. This can be used to reduce the complexity of the data and identify patterns in the data.

Structural Equation Modeling (SEM)

SEM is a statistical technique used to model complex relationships between variables. It can be used to test complex theories and models of causality.

Cluster Analysis

Cluster analysis is used to group similar cases or observations together based on similarities or differences in their characteristics.

Time Series Analysis

Time series analysis is used to analyze data collected over time in order to identify trends, patterns, or changes in the data.

Multilevel Modeling

Multilevel modeling is used to analyze data that is nested within multiple levels, such as students nested within schools or employees nested within companies.

Applications of Experimental Design 

Experimental design is a versatile research methodology that can be applied in many fields. Here are some applications of experimental design:

• Medical Research: Experimental design is commonly used to test new treatments or medications for various medical conditions. This includes clinical trials to evaluate the safety and effectiveness of new drugs or medical devices.
• Agriculture : Experimental design is used to test new crop varieties, fertilizers, and other agricultural practices. This includes randomized field trials to evaluate the effects of different treatments on crop yield, quality, and pest resistance.
• Environmental science: Experimental design is used to study the effects of environmental factors, such as pollution or climate change, on ecosystems and wildlife. This includes controlled experiments to study the effects of pollutants on plant growth or animal behavior.
• Psychology : Experimental design is used to study human behavior and cognitive processes. This includes experiments to test the effects of different interventions, such as therapy or medication, on mental health outcomes.
• Engineering : Experimental design is used to test new materials, designs, and manufacturing processes in engineering applications. This includes laboratory experiments to test the strength and durability of new materials, or field experiments to test the performance of new technologies.
• Education : Experimental design is used to evaluate the effectiveness of teaching methods, educational interventions, and programs. This includes randomized controlled trials to compare different teaching methods or evaluate the impact of educational programs on student outcomes.
• Marketing : Experimental design is used to test the effectiveness of marketing campaigns, pricing strategies, and product designs. This includes experiments to test the impact of different marketing messages or pricing schemes on consumer behavior.

Examples of Experimental Design 

Here are some examples of experimental design in different fields:

• Example in Medical research : A study that investigates the effectiveness of a new drug treatment for a particular condition. Patients are randomly assigned to either a treatment group or a control group, with the treatment group receiving the new drug and the control group receiving a placebo. The outcomes, such as improvement in symptoms or side effects, are measured and compared between the two groups.
• Example in Education research: A study that examines the impact of a new teaching method on student learning outcomes. Students are randomly assigned to either a group that receives the new teaching method or a group that receives the traditional teaching method. Student achievement is measured before and after the intervention, and the results are compared between the two groups.
• Example in Environmental science: A study that tests the effectiveness of a new method for reducing pollution in a river. Two sections of the river are selected, with one section treated with the new method and the other section left untreated. The water quality is measured before and after the intervention, and the results are compared between the two sections.
• Example in Marketing research: A study that investigates the impact of a new advertising campaign on consumer behavior. Participants are randomly assigned to either a group that is exposed to the new campaign or a group that is not. Their behavior, such as purchasing or product awareness, is measured and compared between the two groups.
• Example in Social psychology: A study that examines the effect of a new social intervention on reducing prejudice towards a marginalized group. Participants are randomly assigned to either a group that receives the intervention or a control group that does not. Their attitudes and behavior towards the marginalized group are measured before and after the intervention, and the results are compared between the two groups.

When to use Experimental Research Design 

Experimental research design should be used when a researcher wants to establish a cause-and-effect relationship between variables. It is particularly useful when studying the impact of an intervention or treatment on a particular outcome.

Here are some situations where experimental research design may be appropriate:

• When studying the effects of a new drug or medical treatment: Experimental research design is commonly used in medical research to test the effectiveness and safety of new drugs or medical treatments. By randomly assigning patients to treatment and control groups, researchers can determine whether the treatment is effective in improving health outcomes.
• When evaluating the effectiveness of an educational intervention: An experimental research design can be used to evaluate the impact of a new teaching method or educational program on student learning outcomes. By randomly assigning students to treatment and control groups, researchers can determine whether the intervention is effective in improving academic performance.
• When testing the effectiveness of a marketing campaign: An experimental research design can be used to test the effectiveness of different marketing messages or strategies. By randomly assigning participants to treatment and control groups, researchers can determine whether the marketing campaign is effective in changing consumer behavior.
• When studying the effects of an environmental intervention: Experimental research design can be used to study the impact of environmental interventions, such as pollution reduction programs or conservation efforts. By randomly assigning locations or areas to treatment and control groups, researchers can determine whether the intervention is effective in improving environmental outcomes.
• When testing the effects of a new technology: An experimental research design can be used to test the effectiveness and safety of new technologies or engineering designs. By randomly assigning participants or locations to treatment and control groups, researchers can determine whether the new technology is effective in achieving its intended purpose.

How to Conduct Experimental Research

Here are the steps to conduct Experimental Research:

• Identify a Research Question : Start by identifying a research question that you want to answer through the experiment. The question should be clear, specific, and testable.
• Develop a Hypothesis: Based on your research question, develop a hypothesis that predicts the relationship between the independent and dependent variables. The hypothesis should be clear and testable.
• Design the Experiment : Determine the type of experimental design you will use, such as a between-subjects design or a within-subjects design. Also, decide on the experimental conditions, such as the number of independent variables, the levels of the independent variable, and the dependent variable to be measured.
• Select Participants: Select the participants who will take part in the experiment. They should be representative of the population you are interested in studying.
• Randomly Assign Participants to Groups: If you are using a between-subjects design, randomly assign participants to groups to control for individual differences.
• Conduct the Experiment : Conduct the experiment by manipulating the independent variable(s) and measuring the dependent variable(s) across the different conditions.
• Analyze the Data: Analyze the data using appropriate statistical methods to determine if there is a significant effect of the independent variable(s) on the dependent variable(s).
• Draw Conclusions: Based on the data analysis, draw conclusions about the relationship between the independent and dependent variables. If the results support the hypothesis, then it is accepted. If the results do not support the hypothesis, then it is rejected.
• Communicate the Results: Finally, communicate the results of the experiment through a research report or presentation. Include the purpose of the study, the methods used, the results obtained, and the conclusions drawn.

Purpose of Experimental Design 

The purpose of experimental design is to control and manipulate one or more independent variables to determine their effect on a dependent variable. Experimental design allows researchers to systematically investigate causal relationships between variables, and to establish cause-and-effect relationships between the independent and dependent variables. Through experimental design, researchers can test hypotheses and make inferences about the population from which the sample was drawn.

Experimental design provides a structured approach to designing and conducting experiments, ensuring that the results are reliable and valid. By carefully controlling for extraneous variables that may affect the outcome of the study, experimental design allows researchers to isolate the effect of the independent variable(s) on the dependent variable(s), and to minimize the influence of other factors that may confound the results.

Experimental design also allows researchers to generalize their findings to the larger population from which the sample was drawn. By randomly selecting participants and using statistical techniques to analyze the data, researchers can make inferences about the larger population with a high degree of confidence.

Overall, the purpose of experimental design is to provide a rigorous, systematic, and scientific method for testing hypotheses and establishing cause-and-effect relationships between variables. Experimental design is a powerful tool for advancing scientific knowledge and informing evidence-based practice in various fields, including psychology, biology, medicine, engineering, and social sciences.

Advantages of Experimental Design 

Experimental design offers several advantages in research. Here are some of the main advantages:

• Control over extraneous variables: Experimental design allows researchers to control for extraneous variables that may affect the outcome of the study. By manipulating the independent variable and holding all other variables constant, researchers can isolate the effect of the independent variable on the dependent variable.
• Establishing causality: Experimental design allows researchers to establish causality by manipulating the independent variable and observing its effect on the dependent variable. This allows researchers to determine whether changes in the independent variable cause changes in the dependent variable.
• Replication : Experimental design allows researchers to replicate their experiments to ensure that the findings are consistent and reliable. Replication is important for establishing the validity and generalizability of the findings.
• Random assignment: Experimental design often involves randomly assigning participants to conditions. This helps to ensure that individual differences between participants are evenly distributed across conditions, which increases the internal validity of the study.
• Precision : Experimental design allows researchers to measure variables with precision, which can increase the accuracy and reliability of the data.
• Generalizability : If the study is well-designed, experimental design can increase the generalizability of the findings. By controlling for extraneous variables and using random assignment, researchers can increase the likelihood that the findings will apply to other populations and contexts.

Limitations of Experimental Design

Experimental design has some limitations that researchers should be aware of. Here are some of the main limitations:

• Artificiality : Experimental design often involves creating artificial situations that may not reflect real-world situations. This can limit the external validity of the findings, or the extent to which the findings can be generalized to real-world settings.
• Ethical concerns: Some experimental designs may raise ethical concerns, particularly if they involve manipulating variables that could cause harm to participants or if they involve deception.
• Participant bias : Participants in experimental studies may modify their behavior in response to the experiment, which can lead to participant bias.
• Limited generalizability: The conditions of the experiment may not reflect the complexities of real-world situations. As a result, the findings may not be applicable to all populations and contexts.
• Cost and time : Experimental design can be expensive and time-consuming, particularly if the experiment requires specialized equipment or if the sample size is large.
• Researcher bias : Researchers may unintentionally bias the results of the experiment if they have expectations or preferences for certain outcomes.
• Lack of feasibility : Experimental design may not be feasible in some cases, particularly if the research question involves variables that cannot be manipulated or controlled.

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Research Design 101: Research Methods for Students

Which of the many different types of research design is best for you?

One thing that you will want to consider early in your dissertation process is the design of your research study. By the time you start your dissertation or thesis, you have probably taken graduate and undergraduate courses about research methods; however, it has probably been a while since you have taken these courses, and you may need help sorting through all the different types of research design. Below is a brief refresher on different research designs and methodologies.

General Types of Research Designs

Descriptive: Researchers use descriptive research designs to describe particular phenomena or relationships within a single group sample. Descriptive designs are typically used as either pilot or preliminary studies and generally have rather basic statistical procedures. By nature, descriptive studies do not and cannot be used to explain causation.

Descriptive research designs usually provide researchers with information about a group or phenomenon about which there has been little research (e.g., mating patterns of Martians). However, descriptive studies lack randomization and control and cannot be used to determine causation and other implications; in other words, descriptive research designs can only be used to determine “who” and “what,” not “why.”

Quasi-Experimental: Researchers use quasi-experimental research designs to identify differences between two or more groups in an attempt to explain causation. What keeps these types of experiments from being true experiments is lack of randomization. For example, researchers cannot randomly assign gender to participants; therefore, any study in which researchers are investigating differences between genders is inherently quasi-experimental.

Quasi-experimental designs allow researchers more control to make assumptions about causation and implications of findings. Quasi-experimental designs are also useful when researchers want to study particular groups in which group members cannot be randomly assigned (e.g., persons with depression, single mothers, people from different races or ethnic groups, etc.). A major drawback to using quasi-experimental designs is that quasi-experimental research designs typically have less internal validity than do true experimental designs.

Experimental: Experimental research designs have the most control, and, thus, allow researchers to explain differences between groups. One of the key features of an experimental design is that participants are randomly assigned to groups. Experimental designs can be used to test differences between groups (e.g., treatment a group, treatment b group, and control group) or factorial differences within multiple levels of each group (e.g., a drug group [Xanax or Valium] and a psychotherapy group [Cognitive Behavioral Therapy or Rational Emotive Behavioral Therapy]).

True experimental research designs are understood to be the gold standard of research because experimental research designs are the best designs for researchers to predict causation. However, true experimental designs often require more resources than do other research designs and will not work with all research questions.

Specific Types of Research Designs

Single-Sample Repeated Measures: A design method in which the same group is tested at multiple points in time. Giving students an assessment of knowledge the first day of class and giving the same assessment on the last day of class is an example of a research design based on a single-sample repeated measures.

ABA: A specific single-sample repeated measures design in which participants are measured at baseline (A), after an intervention (B), and again after the intervention has been removed (A).

Between Groups: A design in which researchers compare the scores of two or more groups. Between-group designs can be used as either a single or repeated measure.

Matched Sample: A specific between-groups design in which researchers match participants across groups based on criteria determined by the researchers (e.g., age, IQ, gender, etc.). After matching participants based on the predetermined criteria, researchers examine differences between matched pairs (not between group means).

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AN EXPERIMENTAL STUDY ON THE EFFECT OF PARTS STRATEGY AND ANXIETY ON READING COMPETENCY AT THE ELEVENTH GRADE STUDENTS OF SMAN 5 DENPASAR

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Biology 194A,B: Experimental Thesis

The laboratory/field experimental research thesis.

The experimental thesis option requires that you complete an original research project, either in the laboratory or in the field, and submit a scientific paper describing that research. You will spend most of your efforts in this option testing and modifying your experimental design, conducting your experiments, and analyzing your results. The written product of this work will be similar in format to formal lab reports you have written in biology classes, although all aspects of your thesis will be much more extensive than a lab paper for a class.

Outline of Research

(included in the senior exercise contract):  For an experimental thesis, you must arrange for a place to carry out your research.  Typically, this would be in the lab of (one of) your reader(s).  You must discuss with your reader(s) what your needs will be for such things as facilities, equipment, supplies, and field sites.  In fact, you should give these matters considerable thought prior to approaching a potential experimental thesis reader. You will submit a list of your research needs along with the senior exercise contract so that the department can determine how we can best meet these needs.  The department will provide modest funding for expenses incurred in research ($500)/student), but it is unlikely that we will purchase specialized equipment just for senior projects.  You may NOT use department vehicles for regular transportation to a field site. For several reasons it is essential that you discuss your research needs with your thesis advisor(s) first and use his/her suggestions in drafting your list of research requirements.  You may be able to use equipment and/or supplies available through your reader(s), and all reimbursements must be approved prior to purchase by your thesis advisor(s).   In addition to a list of your research needs, you must also write an abstract that describes the problem you plan to address, the experimental approach you plan to take and a proposed calendar (time-line) for your research.

Progress Report

This is a non-graded (P/NC), written report that describes the early progress you have made in obtaining experimental results and is due part way through the fall semester (see Deadlines, p. 14).  The purpose of this report is to demonstrate to your reader(s) that you have made reasonable progress in tackling your proposed thesis problem, have clearly identified any unforeseen obstacles, and have a plan to resolve them over the course of the remaining weeks of the semester.  We want to know in detail how successful your experimental design has been to date and any problems you have encountered.  You must receive a passing grade on this progress report in order to proceed with your thesis for the rest of the semester.

1 st Semester Draft

This is a graded, written report that is a permanent grade on your transcript for Bio 194A and is due on the last day of classes, Fall Semester.  This paper must include a complete, critical literature review of your topic, your materials and methods section, results to date along with any conclusions that can be drawn from the data you report, and the literature cited section.  Your readers will expect the Introduction, Materials and Methods and Literature Cited sections to essentially complete and polished.  You will report results of experiments in progress, so the Results and Discussion sections will be considerably less complete than those in the final, second semester version. You will receive one credit for this course and a letter grade. It will appear on your transcript as “Experimental Thesis (1 st half).” A passing grade in Bio 194A is a requirement for enrollment in Bio 194B.

Complete Draft/Final Revised Version

These are both graded final reports of your research, written in the format of a scientific paper, which includes an abstract, introduction with literature review and analysis, materials and methods, results, discussion with conclusions, and a complete literature cited section.  You will receive one credit for this course and a letter grade. It will appear on your transcript as “Experimental Thesis (2nd half).”

Public Presentation

All experimental thesis students are required to deliver a public presentation to students and faculty in a forum at the end of the Spring Semester, usually held on the last Friday of classes.

You must write your thesis in the format of a scientific journal paper, the sections of which are described below.

A good title is brief and informative. Try to encapsulate the research topic and objectives – i.e. what your thesis is about.  Humor is not appropriate in a thesis title.

This short paragraph summarizes the entire thesis: the question you asked, the hypothesis you proposed, the approach you took, the results you predicted, the most important, specific (quantitative) results that you obtained, and the conclusions you drew.  Refer to your experimental organism(s) by scientific name(s).  The reader should be able to understand the purpose and conclusions of your study by reading this brief statement: it must be able to stand alone.  Often a reader reads only your abstract.  It is always best to write the abstract last, but it should not be merely a duplicate of your conclusions.  Do not just cut and paste from other sections; write the abstract in its own, very concise style.

Introduction

In a typical research paper, this section briefly covers the general nature of the problem and the significance of the study; that is, why you undertook the study and what you hoped to learn. For a thesis, however, it is necessary to include an historical overview of your problem, its background, and its significance. This section will consist of a critical review of the work that has already been carried out in the field and define the question and hypothesis you propose to test. Critically discuss the background information relevant to the problem you have chosen to study; show why this problem is scientifically interesting and worth investigating experimentally. You should not merely state the conclusions of the work you are reviewing; instead, briefly describe the experiments, the actual results (in quantitative terms whenever possible), and THEN what the results mean.  Do you agree with the interpretation of the results?  Did the investigators use the most appropriate approach(es) to address their question?  Taken together, the background information you present should lead the reader to the inevitable conclusion that it is important to know the answer to the question you have posed and that your hypothesis must be tested.  The relevance of this background information to your research question and hypotheses should be made clear throughout the entire section.

Materials and Methods

What did you do?  Using the past tense, describe your methods concisely but in sufficient detail that your reader could duplicate your techniques.  For field projects, you should describe your study area, how you selected the specific areas sampled or studied, and how you identified your organisms, etc.  Be sure to include scientific names of species studied, your sample sizes, and the types of statistical tests used (if any). Scientific names should be given in full at the first mention, and thereafter the genus (but not the species) can be abbreviated to the initial, e.g., C. annuum.

What did you find out?  Concisely present the results of your experiments and observations in words.  Also include tables, graphs, diagrams, maps, etc., where appropriate. Be sure that all figures and tables are numbered, and referred to in the text by their numbers.  Your text should describe the content of figures and tables, and the significance levels resulting from statistical analyses, but it should not attempt to explain these results; leave this for your Discussion.  Biology is a quantitative science, so be as quantitative as possible: it is much more informative to state that "species X has density of 34 + 5 m -2  at site A and 5 + 2 m -2  at site B" than "species X is more abundant at site A than at site B".  Tables should include pertinent summarizing data such as mean values (± Standard error), and not merely exhaustive lists of primary data.  All numerical data must abide by the significant digits allowed by the measurements themselves and subsequent calculations using measured values.   Insert your Tables and Figures at the appropriate places in the text.

What does it all mean?  In this section you evaluate and explain your data and other results, and discuss them in relation to other similar studies reported in the literature.  As always, when you make a statement of fact beyond common knowledge, you must give a reference to that statement in the form of a text citation, using proper format (see TEXT CITATIONS on pp. 9-10 for details).  In the text of your paper, the literature should be referred to as follows:  "Lopez (2004) stated that . . ..", or, "The animals were observed to blah blah blah (Kuwahara and Schmidt, 1999)".  Examine your data carefully, and then make the most informative and informed statements about them that you can.  Distinguish between clear conclusions that derive from your study, and what is merely indicated or suggested.  Discuss specific items of interest, such as (in the above example) why you think Species X is more abundant at site A than at site B.  Discuss the significance of your study, both in relation to the specifics of your experimental system, and to more general principles of biology.  You may find it appropriate to include brief comments on the accuracy, adequacy, and limitations of your own study, difficulties encountered, possible ways to circumvent these in the future, and ideas for future work, etc.

Conclusions

The Conclusions section is not the same as the Abstract.  Rather, it should contain a brief summary of your results, stated as conclusions, and nothing more.  Listing them as bulleted points is one convenient way to present them.  Be certain that these conclusions are fully justified by your data.

Acknowledgements

In this section you acknowledge help you received during any aspect of your project, including data and suggestions you received from others, as well as funding you or your advisor may have received from outside the department.  It is always acceptable to discuss laboratory and field activities with others and to analyze data as a group, and you are free to discuss your ideas with others; scientists do this all the time.  It is very important, however, that the final thesis document represent your own original thoughts, organization, and expression.  It is always appropriate to recognize and thank those who have significantly assisted you with laboratory or fieldwork, calculations, or the formulations of ideas, e.g., "I thank my roommate Al Gnowing for many stimulating discussions and my advisor Dr. Nobel for teaching me how to use high explosives safely."

Literature Cited

This section is always the last of your thesis, and must include every paper you have cited in the text, and only those papers.  See pp. 9-10 for a description of how to present your literature citations.

Fall Experimental Thesis 194A

Spring Experimental Thesis 194B

*** Turn a hard copy of the final version to each reader. You must also turn in the complete drafts, with the reader's comments, when you turn in the final draft.   Also submit the final version on a CD in either pdf or Word format to Dr. Karnovsky.  Links to the abstracts may be put on the Department web page, and the full electronic version of your thesis will be available to future students for several years. Please remember to put page numbers on ALL written material given to readers for feedback.  When handing in your draft and final version to your readers, you should determine when you can pick up the graded and critiqued copy.  Be sure to get your graded progress report back from faculty readers before the course drop deadline.

Please remember to put page numbers on ALL written material given to readers for feedback. When handing in your draft and final version to your readers, you should determine when you can pick up the graded and critiqued copy. Be sure to get your graded progress report back from faculty readers before the course drop deadline.

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Hägeli Lohaus, Stefan P. (2023) Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/5sb5-fm96. The macroscopic thermophysical behavior of materials is governed by their atomic level excitations and how they store heat. Most of the thermal energy excites oscillations of the atoms, quantized as phonons, but in magnetic materials a considerable amount of heat is also absorbed by fluctuations of the electronic spins. This thesis explores the thermodynamics of phonons and magnetic spins in Fe-systems: we investigate the coupling between these excitations in Fe, Fe-Ni, and Fe-C, quantify their size dependency in nanocrystalline in Ni₃Fe, and assess their individual roles in the anomalous thermal expansion of Fe-Ni Invar. Most materials expand when heated due to enhanced atomic oscillations. However, in 1895 C.E. Guillaume combined Fe and Ni to discover a material with near-zero thermal expansion, called . This discovery was awarded the 1920 Physics Nobel Prize and sparked thousands of scientific investigations. Since the anomalous Invar effect is associated with magnetism, nearly all studies have focused on the electronic and spin structure of Fe-Ni. But phonons are needed to complete the picture, and to date, the anomalous Invar behavior is not fully understood. Here, we explore a method for measuring thermal expansion that is capable of isolating contributions from phonons and spins. Since the thermal energy of materials is related to entropy, the thermal expansion can be indirectly determined through individual entropic contributions by using a Maxwell relation. The phonon and magnetic entropies were measured by combining two nuclear resonant x-ray scattering techniques, with samples under pressure in diamond-anvil cells. We show that the Invar behavior stems from a competition between phonons and spins, that oppose each other for near-zero thermal expansion. A spin-phonon coupling improves the precision of this cancellation, extending the range of Invar behavior. Such a coupling of phonons and spin was also observed in pure Fe and Fe₃C cementite, as their phonon energies correlate to the change in magnetization. This motivated us to develop a magnetic quasi-harmonic model for Fe and Fe₃C, which accounts well for the deviation of phonon energies from pure volumetric effects of the conventional quasi-harmonic approximation. The thermodynamics of materials is also affected by the size of their crystallites. We determined the size effects on the heat absorption by phonons, electrons, and spins in nanocrystalline Ni₃Fe. All excitations become enhanced in the nanomaterial. In particular, the redistribution of spectral weights amplifies the phonon entropy. This helps stabilize the nanostructure against the enthalpy from its extra grain boundaries. However, the nanostructure is meta-stable, and the grains will grow into their bulk counterpart when diffusion is enabled at elevated temperatures. Item Type: Thesis (Dissertation (Ph.D.)) Subject Keywords: Thermodynamics, Materials Science Degree Grantor: California Institute of Technology Division: Engineering and Applied Science Major Option: Materials Science Thesis Availability: Public (worldwide access) Research Advisor(s): Thesis Committee: Defense Date: 5 May 2023 Funders: Funding Agency Grant Number National Science Foundation 1904714 Department of Energy (DOE) DE-FG02-03ER46055 URL URL Type Description DOI Article related to Chapter 3 "Thermodynamic stability and heat absorption of nanocrystalline Ni3Fe" DOI Article related to Chapter 4 "Magnetic quasi-harmonic model for Fe and Fe3C" Author ORCID Hägeli Lohaus, Stefan P. Thesis Files - Final Version 25MB Repository Staff Only: item control page Skip to main content Skip to primary sidebar Skip to footer QuestionPro Solutions Industries Gaming Automotive Sports and events Education Government Travel & Hospitality Financial Services Healthcare Cannabis Technology Use Case AskWhy Communities Audience Contactless surveys Mobile LivePolls Member Experience GDPR Positive People Science 360 Feedback Surveys Resources Blog eBooks Survey Templates Case Studies Training Help center Home Market Research Experimental vs Observational Studies: Differences & Examples Understanding the differences between experimental vs observational studies is crucial for interpreting findings and drawing valid conclusions. Both methodologies are used extensively in various fields, including medicine, social sciences, and environmental studies.  Researchers often use observational and experimental studies to gather comprehensive data and draw robust conclusions about their investigating phenomena.  This blog post will explore what makes these two types of studies unique, their fundamental differences, and examples to illustrate their applications. What is an Experimental Study? An experimental study is a research design in which the investigator actively manipulates one or more variables to observe their effect on another variable. This type of study often takes place in a controlled environment, which allows researchers to establish cause-and-effect relationships. Key Characteristics of Experimental Studies: Manipulation: Researchers manipulate the independent variable(s). Control: Other variables are kept constant to isolate the effect of the independent variable. Randomization: Subjects are randomly assigned to different groups to minimize bias. Replication: The study can be replicated to verify results. Types of Experimental Study Laboratory Experiments: Conducted in a controlled environment where variables can be precisely controlled. Field Research : These are conducted in a natural setting but still involve manipulation and control of variables. Clinical Trials: Used in medical research and the healthcare industry to test the efficacy of new treatments or drugs. Example of an Experimental Study: Imagine a study to test the effectiveness of a new drug for reducing blood pressure. Researchers would: Randomly assign participants to two groups: receiving the drug and receiving a placebo. Ensure that participants do not know their group (double-blind procedure). Measure blood pressure before and after the intervention. Compare the changes in blood pressure between the two groups to determine the drug’s effectiveness. What is an Observational Study? An observational study is a research design in which the investigator observes subjects and measures variables without intervening or manipulating the study environment. This type of study is often used when manipulating impractical or unethical variables. Key Characteristics of Observational Studies: No Manipulation: Researchers do not manipulate the independent variable. Natural Setting: Observations are made in a natural environment. Causation Limitations: It is difficult to establish cause-and-effect relationships due to the need for more control over variables. Descriptive: Often used to describe characteristics or outcomes. Types of Observational Studies:  Cohort Studies : Follow a control group of people over time to observe the development of outcomes. Case-Control Studies: Compare individuals with a specific outcome (cases) to those without (controls) to identify factors that might contribute to the outcome. Cross-Sectional Studies : Collect data from a population at a single point to analyze the prevalence of an outcome or characteristic. Example of an Observational Study: Consider a study examining the relationship between smoking and lung cancer. Researchers would: Identify a cohort of smokers and non-smokers. Follow both groups over time to record incidences of lung cancer. Analyze the data to observe any differences in cancer rates between smokers and non-smokers. Difference Between Experimental vs Observational Studies Topic Experimental Studies Observational Studies Manipulation Yes No Control High control over variables Little to no control over variables Randomization Yes, often, random assignment of subjects No random assignment Environment Controlled or laboratory settings Natural or real-world settings Causation Can establish causation Can identify correlations, not causation Ethics and Practicality May involve ethical concerns and be impractical More ethical and practical in many cases Cost and Time Often more expensive and time-consuming Generally less costly and faster Choosing Between Experimental and Observational Studies The researchers relied on statistical analysis to interpret the results of randomized controlled trials, building upon the foundations established by prior research. Use Experimental Studies When: Causality is Important: If determining a cause-and-effect relationship is crucial, experimental studies are the way to go. Variables Can Be Controlled: When you can manipulate and control the variables in a lab or controlled setting, experimental studies are suitable. Randomization is Possible: When random assignment of subjects is feasible and ethical, experimental designs are appropriate. Use Observational Studies When: Ethical Concerns Exist: If manipulating variables is unethical, such as exposing individuals to harmful substances, observational studies are necessary. Practical Constraints Apply: When experimental studies are impractical due to cost or logistics, observational studies can be a viable alternative. Natural Settings Are Required: If studying phenomena in their natural environment is essential, observational studies are the right choice. Strengths and Limitations Experimental studies. Establish Causality: Experimental studies can establish causal relationships between variables by controlling and using randomization. Control Over Confounding Variables: The controlled environment allows researchers to minimize the influence of external variables that might skew results. Repeatability: Experiments can often be repeated to verify results and ensure consistency. Limitations: Ethical Concerns: Manipulating variables may be unethical in certain situations, such as exposing individuals to harmful conditions. Artificial Environment: The controlled setting may not reflect real-world conditions, potentially affecting the generalizability of results. Cost and Complexity: Experimental studies can be costly and logistically complex, especially with large sample sizes. Observational Studies Real-World Insights: Observational studies provide valuable insights into how variables interact in natural settings. Ethical and Practical: These studies avoid ethical concerns associated with manipulation and can be more practical regarding cost and time. Diverse Applications: Observational studies can be used in various fields and situations where experiments are not feasible. Lack of Causality: It’s easier to establish causation with manipulation, and results are limited to identifying correlations. Potential for Confounding: Uncontrolled external variables may influence the results, leading to biased conclusions. Observer Bias: Researchers may unintentionally influence outcomes through their expectations or interpretations of data. Examples in Various Fields Experimental Study: Clinical trials testing the effectiveness of a new drug against a placebo to determine its impact on patient recovery. Observational Study: Studying the dietary habits of different populations to identify potential links between nutrition and disease prevalence. Experimental Study: Conducting a lab experiment to test the effect of sleep deprivation on cognitive performance by controlling sleep hours and measuring test scores. Observational Study: Observing social interactions in a public setting to explore natural communication patterns without intervention. Environmental Science Experimental Study: Testing the impact of a specific pollutant on plant growth in a controlled greenhouse setting. Observational Study: Monitoring wildlife populations in a natural habitat to assess the effects of climate change on species distribution. How QuestionPro Research Can Help in Experimental vs Observational Studies Choosing between experimental and observational studies is a critical decision that can significantly impact the outcomes and interpretations of a study. QuestionPro Research offers powerful tools and features that can enhance both types of studies, giving researchers the flexibility and capability to gather, analyze, and interpret data effectively. Enhancing Experimental Studies with QuestionPro Experimental studies require a high degree of control over variables, randomization, and, often, repeated trials to establish causal relationships. QuestionPro excels in facilitating these requirements through several key features: Survey Design and Distribution: With QuestionPro, researchers can design intricate surveys tailored to their experimental needs. The platform supports random assignment of participants to different groups, ensuring unbiased distribution and enhancing the study’s validity. Data Collection and Management: Real-time data collection and management tools allow researchers to monitor responses as they come in. This is crucial for experimental studies where data collection timing and sequence can impact the results. Advanced Analytics: QuestionPro offers robust analytical tools that can handle complex data sets, enabling researchers to conduct in-depth statistical analyses to determine the effects of the experimental interventions. Supporting Observational Studies with QuestionPro Observational studies involve gathering data without manipulating variables, focusing on natural settings and real-world scenarios. QuestionPro’s capabilities are well-suited for these studies as well: Customizable Surveys: Researchers can create detailed surveys to capture a wide range of observational data. QuestionPro’s customizable templates and question types allow for flexibility in capturing nuanced information. Mobile Data Collection: For field research, QuestionPro’s mobile app enables data collection on the go, making it easier to conduct studies in diverse settings without internet connectivity. Longitudinal Data Tracking: Observational studies often require data collection over extended periods. QuestionPro’s platform supports longitudinal studies, allowing researchers to track changes and trends. Experimental and observational studies are essential tools in the researcher’s toolkit. Each serves a unique purpose and offers distinct advantages and limitations. By understanding their differences, researchers can choose the most appropriate study design for their specific objectives, ensuring their findings are valid and applicable to real-world situations. Whether establishing causality through experimental studies or exploring correlations with observational research designs, the insights gained from these methodologies continue to shape our understanding of the world around us.  Whether conducting experimental or observational studies, QuestionPro Research provides a comprehensive suite of tools that enhance research efficiency, accuracy, and depth. By leveraging its advanced features, researchers can ensure that their studies are well-designed, their data is robustly analyzed, and their conclusions are reliable and impactful. MORE LIKE THIS Sep 5, 2024 Interactive Forms: Key Features, Benefits, Uses + Design Tips Sep 4, 2024 Closed-Loop Management: The Key to Customer Centricity Sep 3, 2024 Net Trust Score: Tool for Measuring Trust in Organization Sep 2, 2024 Other categories Academic Research Artificial Intelligence Assessments Brand Awareness Case Studies Communities Consumer Insights Customer effort score Customer Engagement Customer Experience Customer Loyalty Customer Research Customer Satisfaction Employee Benefits Employee Engagement Employee Retention Friday Five General Data Protection Regulation Insights Hub Life@QuestionPro Market Research Mobile diaries Mobile Surveys New Features Online Communities Question Types Questionnaire QuestionPro Products Release Notes Research Tools and Apps Revenue at Risk Survey Templates Training Tips Tuesday CX Thoughts (TCXT) Uncategorized What’s Coming Up Workforce Intelligence Have a language expert improve your writing Run a free plagiarism check in 10 minutes, generate accurate citations for free. Knowledge Base Methodology Quasi-Experimental Design | Definition, Types & Examples Quasi-Experimental Design | Definition, Types & Examples Published on July 31, 2020 by Lauren Thomas . Revised on January 22, 2024. Like a true experiment , a quasi-experimental design aims to establish a cause-and-effect relationship between an independent and dependent variable . However, unlike a true experiment, a quasi-experiment does not rely on random assignment . Instead, subjects are assigned to groups based on non-random criteria. Quasi-experimental design is a useful tool in situations where true experiments cannot be used for ethical or practical reasons. Table of contents Differences between quasi-experiments and true experiments, types of quasi-experimental designs, when to use quasi-experimental design, advantages and disadvantages, other interesting articles, frequently asked questions about quasi-experimental designs. There are several common differences between true and quasi-experimental designs. True experimental design Quasi-experimental design Assignment to treatment The researcher subjects to control and treatment groups. Some other, method is used to assign subjects to groups. Control over treatment The researcher usually . The researcher often , but instead studies pre-existing groups that received different treatments after the fact. Use of Requires the use of . Control groups are not required (although they are commonly used). Example of a true experiment vs a quasi-experiment However, for ethical reasons, the directors of the mental health clinic may not give you permission to randomly assign their patients to treatments. In this case, you cannot run a true experiment. Instead, you can use a quasi-experimental design. You can use these pre-existing groups to study the symptom progression of the patients treated with the new therapy versus those receiving the standard course of treatment. Here's why students love Scribbr's proofreading services Discover proofreading & editing Many types of quasi-experimental designs exist. Here we explain three of the most common types: nonequivalent groups design, regression discontinuity, and natural experiments. Nonequivalent groups design In nonequivalent group design, the researcher chooses existing groups that appear similar, but where only one of the groups experiences the treatment. In a true experiment with random assignment , the control and treatment groups are considered equivalent in every way other than the treatment. But in a quasi-experiment where the groups are not random, they may differ in other ways—they are nonequivalent groups . When using this kind of design, researchers try to account for any confounding variables by controlling for them in their analysis or by choosing groups that are as similar as possible. This is the most common type of quasi-experimental design. Regression discontinuity Many potential treatments that researchers wish to study are designed around an essentially arbitrary cutoff, where those above the threshold receive the treatment and those below it do not. Near this threshold, the differences between the two groups are often so minimal as to be nearly nonexistent. Therefore, researchers can use individuals just below the threshold as a control group and those just above as a treatment group. However, since the exact cutoff score is arbitrary, the students near the threshold—those who just barely pass the exam and those who fail by a very small margin—tend to be very similar, with the small differences in their scores mostly due to random chance. You can therefore conclude that any outcome differences must come from the school they attended. Natural experiments In both laboratory and field experiments, researchers normally control which group the subjects are assigned to. In a natural experiment, an external event or situation (“nature”) results in the random or random-like assignment of subjects to the treatment group. Even though some use random assignments, natural experiments are not considered to be true experiments because they are observational in nature. Although the researchers have no control over the independent variable , they can exploit this event after the fact to study the effect of the treatment. However, as they could not afford to cover everyone who they deemed eligible for the program, they instead allocated spots in the program based on a random lottery. Although true experiments have higher internal validity , you might choose to use a quasi-experimental design for ethical or practical reasons. Sometimes it would be unethical to provide or withhold a treatment on a random basis, so a true experiment is not feasible. In this case, a quasi-experiment can allow you to study the same causal relationship without the ethical issues. The Oregon Health Study is a good example. It would be unethical to randomly provide some people with health insurance but purposely prevent others from receiving it solely for the purposes of research. However, since the Oregon government faced financial constraints and decided to provide health insurance via lottery, studying this event after the fact is a much more ethical approach to studying the same problem. True experimental design may be infeasible to implement or simply too expensive, particularly for researchers without access to large funding streams. At other times, too much work is involved in recruiting and properly designing an experimental intervention for an adequate number of subjects to justify a true experiment. In either case, quasi-experimental designs allow you to study the question by taking advantage of data that has previously been paid for or collected by others (often the government). Quasi-experimental designs have various pros and cons compared to other types of studies. Higher external validity than most true experiments, because they often involve real-world interventions instead of artificial laboratory settings. Higher internal validity than other non-experimental types of research, because they allow you to better control for confounding variables than other types of studies do. Lower internal validity than true experiments—without randomization, it can be difficult to verify that all confounding variables have been accounted for. The use of retrospective data that has already been collected for other purposes can be inaccurate, incomplete or difficult to access. Receive feedback on language, structure, and formatting Professional editors proofread and edit your paper by focusing on: Academic style Vague sentences Style consistency See an example If you want to know more about statistics , methodology , or research bias , make sure to check out some of our other articles with explanations and examples. Normal distribution Degrees of freedom Null hypothesis Discourse analysis Control groups Mixed methods research Non-probability sampling Quantitative research Ecological validity Research bias Rosenthal effect Implicit bias Cognitive bias Selection bias Negativity bias Status quo bias A quasi-experiment is a type of research design that attempts to establish a cause-and-effect relationship. The main difference with a true experiment is that the groups are not randomly assigned. In experimental research, random assignment is a way of placing participants from your sample into different groups using randomization. With this method, every member of the sample has a known or equal chance of being placed in a control group or an experimental group. Quasi-experimental design is most useful in situations where it would be unethical or impractical to run a true experiment . Quasi-experiments have lower internal validity than true experiments, but they often have higher external validity  as they can use real-world interventions instead of artificial laboratory settings. Cite this Scribbr article If you want to cite this source, you can copy and paste the citation or click the “Cite this Scribbr article” button to automatically add the citation to our free Citation Generator. Thomas, L. (2024, January 22). Quasi-Experimental Design | Definition, Types & Examples. Scribbr. Retrieved September 5, 2024, from https://www.scribbr.com/methodology/quasi-experimental-design/ Is this article helpful? Lauren Thomas Other students also liked, guide to experimental design | overview, steps, & examples, random assignment in experiments | introduction & examples, control variables | what are they & why do they matter, what is your plagiarism score. Master's programmes in English For exchange students PhD opportunities All programmes of study Language requirements Application process Academic calendar NTNU research Research excellence Strategic research areas Innovation resources Student in Trondheim Student in Gjøvik Student in Ålesund For researchers Life and housing Faculties and departments International researcher support Språkvelger Course - master's thesis in general psychology - psy3915, course-details-portlet, psy3915 - master's thesis in general psychology, examination arrangement. Examination arrangement: Master thesis and oral examination Grade: Letter grades Evaluation Weighting Duration Grade deviation Examination aids Master thesis and oral examination 100/100 Course content The Master's thesis is an academic in-depth work within general psychology, where the student writes a scientific document in line with relevant guidelines in regards to structure and theory. The subject of the master's thesis, which can be either experimental or purely theoretical, should be decided in consultation with a competent supervisor. Students apply to have their thesis topic approved and a supervisor appointed by filling in a master's thesis agreement. Here the student must include a project description in which the research purpose, theoretical grounding, methodological approach and practical implementation are explained. Check with the department regarding the deadline for submitting this master's thesis agreement. The institute is responsible to assess and approve both topic and supervisor. Learning outcome The student: • has advanced knowledge within general psychology and specialized insight into a limited area • has in-depth knowledge of theory and method in psychological research and of how a scientific project is carried out • has in-depth knowledge of what is required of a scientific text in psychology, including advanced knowledge of APA style • has in-depth knowledge of conducting professional argumentation with the use of theory, research, method and method choice and own data and analysis • has advanced knowledge of quality requirements for research, including adherence to research ethical guidelines and principles • can analyze and relate critically to various sources of information and use these to structure and formulate professional reasoning • can analyze existing theories, methods and interpretations within the subject area and work independently with practical and theoretical problem solving • can use relevant methods for research and professional development independently • can design and carry out an independent, limited research project under supervision and in line with applicable research ethics norms • can analyze professional issues and understand complex research data • can communicate scientific findings - both in writing and orally. • can find out and relate critically to various sources of information • can familiarize themselves with literature that is relevant for carrying out research within a limited area of ​​psychology • can communicate the research work • The student can formulate a precise and clear problem with relevance for psychological theory or practice and present a well-considered rationale for the choice and use of method and literature • The student can think critically and draw scientific conclusions based on research • The student can use the APA standard for scientific publishing General competence: • can analyze relevant professional, professional and research ethical issues • can apply their knowledge and skills in new areas to carry out advanced tasks and projects • can convey extensive independent work and masters the subject's forms of expression • can communicate about professional issues, analyzes and conclusions within psychology • can apply their knowledge to find answers to relevant issues in psychology • can convey extensive independent research work within psychology's forms of expression • can communicate psychological research Learning methods and activities Own work with compulsory guidance. The work on the master's thesis will be a combination of independent activity and work under supervision. The academic guidance must ensure that the student is provided with the necessary knowledge, that all parts of the work have a satisfactory quality (e.g. when collecting and processing data) and that the project as a whole takes place in line with current research ethical guidelines. The master's thesis seminar in the second semester consists of information on how to find a topic, a presentation of potential supervisors and the design of a project description. The master's thesis seminar in the third semester consists of a lecture that gives tips and advice on the process of writing a master's thesis and a seminar where the student presents his topics and receives constructive feedback from other students and staff. Participation in the master's thesis seminars must be approved before submission of the master's thesis can take place. Compulsory assignments Mandatory participation in the thesis seminar Further on evaluation The master's thesis is assessed with letter grades (A-F). The assignment is delivered individually or as a joint work. If the thesis is delivered as joint work, a document describing the individual candidate's contribution must be attached. This will normally involve an individual assessment of the candidates. The students give a final oral presentation and are examined on the assignment. The oral examination consists of an explanation from the student of approx. 10 minutes and a subsequent questioning. Oral examination is used to adjust the grade. The student can choose an open or closed exam. If it is an open examination, the audience may be present during the examination, if it is a closed examination, only the committee and the student are present. Check with the institute for the deadline for submitting the project description and master's thesis. Specific conditions Admission to a programme of study is required: Psychology (MPSY) Required previous knowledge All examinations in the Masters in General Psychology should be passed before the thesis can be submitted. Version: 1 Credits:  45.0 SP Study level: Second degree level Term no.: 1 Teaching semester:  AUTUMN 2024 Term no.: 2 Teaching semester:  SPRING 2025 Language of instruction: English, Norwegian Location: Trondheim Audrey Lucia Hendrika van der Meer Roxanna Morote Rios Department with academic responsibility Department of Psychology Examination Examination arrangement: master thesis and oral examination. Room Building Number of candidates * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb. For more information regarding registration for examination and examination procedures, see "Innsida - Exams" More on examinations at NTNU 276 IMAGES Experimental Research Thesis Examples Pdf (PDF) Experimental Research Methods for Students in Built Environment Experimental Research Thesis Examples Pdf 10 Real-Life Experimental Research Examples (2024) Experimental Research Thesis Examples Pdf (PDF) Experimental Research Design: A Play of Variables VIDEO Thesis Writing Service #thesiswriting #academicwriting #studymotivation Thesis Experimental Video CHARACTERISTICS OF EXPERIMENTAL RESEARCH Research Design vs. Research Methods: Understanding the Key Differences #dataanalysis #thesis Thesis Writing Experimental Research COMMENTS Exploring Experimental Research: Methodologies, Designs, and Experimental research serves as a fundamental scientific method aimed at unraveling. cause-and-effect relationships between variables across various disciplines. This. paper delineates the key ... Guide to Experimental Design Guide to Experimental Design | Overview, 5 steps & Examples. Published on December 3, 2019 by Rebecca Bevans.Revised on June 21, 2023. Experiments are used to study causal relationships.You manipulate one or more independent variables and measure their effect on one or more dependent variables.. Experimental design create a set of procedures to systematically test a hypothesis. Study/Experimental/Research Design: Much More Than Statistics Study, experimental, or research design is the backbone of good research. It directs the experiment by orchestrating data collection, defines the statistical analysis of the resultant data, and guides the interpretation of the results. When properly described in the written report of the experiment, it serves as a road map to readers, 1 helping ... Clinical research study designs: The essentials The experimental study design can be classified into 2 groups, that is, controlled (with comparison) and uncontrolled (without comparison). 1 In the group without controls, the outcome is directly attributed to the treatment received in one group. This fails to prove if the outcome was truly due to the intervention implemented or due to chance. PDF Three Experimental Studies of Reward and Decision Making Three Experimental Studies of Reward and Decision Making Thesis by Min Jeong Kang In Partial Fulfillment of the Requirements for the Degree of ... This thesis investigates reward-driven decision making using a combination of techniques such as functional neuroimaging, behavioral experiments, and pupilometry. ... Experimental Research Designs: Types, Examples & Methods The pre-experimental research design is further divided into three types. One-shot Case Study Research Design. In this type of experimental study, only one dependent group or variable is considered. The study is carried out after some treatment which was presumed to cause change, making it a posttest study. Experimental Research Designs: Types, Examples & Advantages Pre-experimental research is of three types —. One-shot Case Study Research Design. One-group Pretest-posttest Research Design. Static-group Comparison. 2. True Experimental Research Design. A true experimental research design relies on statistical analysis to prove or disprove a researcher's hypothesis. An introduction to different types of study design We may approach this study by 2 longitudinal designs: Prospective: we follow the individuals in the future to know who will develop the disease. Retrospective: we look to the past to know who developed the disease (e.g. using medical records) This design is the strongest among the observational studies. For example - to find out the relative ... Writing Center: Experimental Research Papers What is the purpose of an experimental research paper? A research paper is intended to inform others about advancement in a particular field of study. The researcher who wrote the paper identified a gap in the research in a field of study and used their research to help fill this gap. ... Create a clear research question, hypothesis, or thesis ... A Quick Guide to Experimental Design Step 1: Define your variables. You should begin with a specific research question. We will work with two research question examples, one from health sciences and one from ecology: Example question 1: Phone use and sleep. You want to know how phone use before bedtime affects sleep patterns. PDF Chapter 3 Experimental Methodology Chapter 3. ental Methodology3.1 IntroductionIn this chapter I describe the experimental methodo. ogy adopted throughout the thesis. This includes the datasets selected as the testbed for. the retrieval experiments (Section3.2), the definition of groundtruth for evaluation (Section 3.3) and the metrics adopted to ascertain ret. Guide to experimental research design Experimental design is a research method that enables researchers to assess the effect of multiple factors on an outcome.. You can determine the relationship between each of the variables by: Manipulating one or more independent variables (i.e., stimuli or treatments). Applying the changes to one or more dependent variables (i.e., test groups or outcomes) Chapter 10 Experimental Research Chapter 10 Experimental Research. Experimental research, often considered to be the "gold standard" in research designs, is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different treatment levels ... Experimental Design Experimental design is a process of planning and conducting scientific experiments to investigate a hypothesis or research question. It involves carefully designing an experiment that can test the hypothesis, and controlling for other variables that may influence the results. Experimental design typically includes identifying the variables that ... Experimental Research Design An experimental research design is typically focused on the relationship between two variables: the independent variable and the dependent variable. The researcher uses random sampling and random ... 5: Experimental Design Experimental design is a discipline within statistics concerned with the analysis and design of experiments. Design is intended to help research create experiments such that cause and effect can be established from tests of the hypothesis. We introduced elements of experimental design in Chapter 2.4. Here, we expand our discussion of ... Research Design 101: Research Methods for Students Specific Types of Research Designs. Single-Sample Repeated Measures: A design method in which the same group is tested at multiple points in time. Giving students an assessment of knowledge the first day of class and giving the same assessment on the last day of class is an example of a research design based on a single-sample repeated measures. What Is a Research Design A research design is a strategy for answering your research question using empirical data. Creating a research design means making decisions about: Your overall research objectives and approach. Whether you'll rely on primary research or secondary research. Your sampling methods or criteria for selecting subjects. Your data collection methods. An Experimental Study on The Effect of Parts Strategy and Anxiety on Unpublished Thesis. Universitas Pendidikan Ganesha Singaraja. ... This experimental study used 22 students for the experimental group and 22 students for the control group. Types of Research Designs Compared Types of Research Designs Compared | Guide & Examples. Published on June 20, 2019 by Shona McCombes.Revised on June 22, 2023. When you start planning a research project, developing research questions and creating a research design, you will have to make various decisions about the type of research you want to do.. There are many ways to categorize different types of research. PDF An Experimental Study on the Effectiveness of Multimedia Multimedia courseware combines sound, pictures, texts together and it offers a vivid, direct study environment. It has different kinds of forms, exercises, and activities. It can arouse students' interest. It can facilitate English teaching and learning and make it more efficient. Biology 194A,B: Experimental Thesis The Laboratory/Field Experimental Research Thesis The experimental thesis option requires that you complete an original research project, either in the laboratory or in the field, and submit a scientific paper describing that research. You will spend most of your efforts in this option testing and modifying your experimental design, conducting your experiments, and analyzing your results. Experimental Study on the Thermodynamic Interactions of Phonons and Experimental Study on the Thermodynamic Interactions of Phonons and Magnetism in Fe Systems Citation. Hägeli Lohaus, Stefan P. ... This thesis explores the thermodynamics of phonons and magnetic spins in Fe-systems: we investigate the coupling between these excitations in Fe, Fe-Ni, and Fe-C, quantify their size dependency in nanocrystalline ... Experimental vs Observational Studies: Differences & Examples Choosing between experimental and observational studies is a critical decision that can significantly impact the outcomes and interpretations of a study. QuestionPro Research offers powerful tools and features that can enhance both types of studies, giving researchers the flexibility and capability to gather, analyze, and interpret data ... Quasi-Experimental Design True experimental design Quasi-experimental design; Assignment to treatment: The researcher randomly assigns subjects to control and treatment groups.: Some other, non-random method is used to assign subjects to groups. Control over treatment: The researcher usually designs the treatment.: The researcher often does not have control over the treatment, but instead studies pre-existing groups ... Course The subject of the master's thesis, which can be either experimental or purely theoretical, should be decided in consultation with a competent supervisor. ... Here the student must include a project description in which the research purpose, theoretical grounding, methodological approach and practical implementation are explained. Check with ... essay homework paper phd project resume review study thesis