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In this work we model the glomerular filtration barrier, the structure responsible for filtering the blood and preventing the loss of proteins, using human podocytes and glomerular endothelial cells seeded into micr…
Two novel candidate therapies in clinical development to treat diseases of the glomerular filtration barrier (GFB) include antisense oligonucleotides (ASOs) against …
Immunoglobulin accumulation at the filtration barrier is pathognomonic for glomerular injury. The mechanisms that regulate filter permeability are unknown. Here, we …
The significance of the tri-culture is verified by the glomerular cells filtering human serum albumin, acting as filtration barrier both biologically and mechanically. In this work, the …
Glomerular Filtration. Filtrate is produced by the glomerulus when the hydrostatic pressure produced by the heart pushes water and solutes through the filtration membrane. …
This discussion focuses on the regulation of filtration at the level of a single, typical glomerulus, by which the precise hemodynamic control of glomerular filtration is best understood.
The measurement of glomerular filtration rate (GFR) is the gold standard in kidney function assessment. Currently, investigators determine GFR by measuring the level of the …
Loss of podocytes, the cells that together with glomerular endothelial cells (GECs) form the glomerular filtration barrier, are central culprits of most progressive CKD (4–7). Some …
We investigate the potential impact of the electrical field on the passage of albumin across the glomerular filtration barrier. We review the mathematical heteroporous model including …